An Insight into Anti-Inflammatory Activities and Inflammation Related Diseases of Anthocyanins: A Review of Both In Vivo and In Vitro Investigations.

Abstract

Anthocyanin is a type of flavonoid pigment widely present in fruits and vegetables. It can not only be used as natural pigment, but also has a variety of health functions, for instance, anti-oxidant, anti-inflammatory, anti-tumor, and neuroprotective activities. Persistent proinflammatory status is a major factor in the development, progression, and complications of chronic diseases. Not surprisingly, there are thus many food ingredients that can potentially affect inflammation related diseases and many studies have shown that anthocyanins play an important role in inflammatory pathways. In this paper, the inflammation related diseases (such as, obesity, diabetes, cardiovascular disease, and cancer) of anthocyanins are introduced, and the anti-inflammatory effect of anthocyanins is emphatically introduced. Moreover, the anti-inflammatory mechanism of anthocyanins is elaborated from the aspects of NF-κB, toll like receptor, MAPKs, NO, and ROS and the main efficacy of anthocyanins in inflammation and related diseases is determined. In conclusion, this review aims to get a clear insight into the role of anthocyanins in inflammation related diseases.

• Authors: Zilong Ma, Bin Du, Jun Li, Yuedong Yang, Fengmei Zhu
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 22 Issue 20 (Oct 14 2021) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 34681733 (Publication Type: Journal Article, Review)

Chemical References

• Anthocyanins
• Anti-Inflammatory Agents, Non-Steroidal
• Antioxidants
• NF-kappa B
• Dinoprostone

Topics

• Animals
• Anthocyanins (pharmacology)
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Antioxidants (pharmacology)
• Cardiovascular Diseases (drug therapy, etiology)
• Diabetes Mellitus (drug therapy, etiology)
• Dinoprostone (metabolism)
• Humans
• Inflammation (complications, drug therapy)
• MAP Kinase Signaling System (drug effects)
• NF-kappa B (metabolism)
• Neoplasms (drug therapy, etiology)
• Obesity (drug therapy, etiology)