Scutellarin alleviates depression-like behaviors induced by LPS in mice partially through inhibition of astrocyte-mediated neuroinflammation.

Abstract

Depression is a kind of common mental disorder associated with neuroinflammation, and astrocytes play a vital role in regulating and mediating neuroinflammation in central nervous system. Scutellarin has significant anti-inflammatory and neuroprotective effects. However, whether scutellarin exerts antidepressant effect remains unknown. In present study, it was found that scutellarin suppressed LPS-induced neuroinflammation in the hippocampus and alleviated depression-like behaviors in mice. In addition, scutellarin inhibited LPS-induced elevation of TNFα, IL-1β, IL-6 and iNOS, and reversed the downregulation of IL-4 and BDNF in astrocytes in vitro. Furthermore, the activated TLR4/NF-κB pathway in LPS-treated astrocytes was suppressed by scutellarin. Collectively, these results suggest that scutellarin ameliorates depression-like behaviors induced by neuroinflammation partially through inhibiting the TLR4/NF-κB pathway in astrocytes.

• Authors: Liang Lu, Liu-Kun Yang, Jiao Yue, Xin-Shang Wang, Jing-Yu Qi, Fan Yang, Ban Feng, Shui-Bing Liu
• Journal: Neuroscience letters (Neurosci Lett) Vol. 765 Pg. 136284 (11 20 2021) ISSN: 1872-7972 [Electronic] Ireland
• PMID: 34624394 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Glucuronates
• Lipopolysaccharides
• scutellarin
• Apigenin

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Apigenin (pharmacology)
• Astrocytes (drug effects, immunology)
• Depression (immunology)
• Glucuronates (pharmacology)
• Hippocampus (drug effects)
• Lipopolysaccharides (immunology, toxicity)
• Male
• Mice
• Mice, Inbred C57BL
• Neuroinflammatory Diseases (immunology)