Abstract | BACKGROUND: METHODS: RESULTS: After analyzing data from GSE76297, GSE89749, and GSE26566GO, we found 1554 down-regulated and 1065 up-regulated genes. Through Gene Ontology and Kyoto Encyclopedia and Genomes analysis, extracellular matrix organization, extracellular structure organization, cholesterol metabolism, interleukin-17 signaling pathway, and vitamin digestion and absorption were significantly enriched and involved in targeted differentially expresses genes. Epithelial membrane protein 1 messenger ribonucleic acid was notably decreased in serum samples from extrahepatic cholangiocarcinoma patients, compared with that in healthy controls. Receiver operating characteristic analysis revealed that the area under the curve of epithelial membrane protein 1 messenger ribonucleic acid for the diagnosis of extrahepatic cholangiocarcinoma was 0.9281 (95% CI = 0.8967-0.9595). Moreover, the correlation analysis presented that epithelial membrane protein 1 expression was negatively correlated with lymph node metastasis, tumour node metastasis stage, cancer antigen 19-9 level, and carcinoembryonic antigen level. CONCLUSION:
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Authors | Xiang Li, Lang Yan, Hao Xue |
Journal | The International journal of biological markers
(Int J Biol Markers)
Vol. 36
Issue 3
Pg. 33-39
(Sep 2021)
ISSN: 1724-6008 [Electronic] United States |
PMID | 34569869
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Neoplasm Proteins
- Receptors, Cell Surface
- epithelial membrane protein-1
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Topics |
- Bile Duct Neoplasms
(genetics)
- Bile Ducts, Intrahepatic
- Biomarkers, Tumor
(genetics)
- Cholangiocarcinoma
(genetics)
- Humans
- Neoplasm Proteins
- Prognosis
- Receptors, Cell Surface
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