Abstract |
Severe fever with thrombocytopenia syndrome (SFTS) is a new tick-borne viral disease, and most SFTS virus (SFTSV) infections occur via bites from the tick Haemaphysalis longicornis; however, SFTSV transmission can also occur through close contact with an infected patient. SFTS is characterized by acute high fever, thrombocytopenia, leukopenia, elevated serum hepatic enzyme levels, gastrointestinal symptoms, and multiorgan failure and has a 16.2 to 30% mortality rate. In this study, we found that age, dyspnea rates, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase, multiorgan dysfunction score (MODS), viral load, IL-6 levels, and IL-10 levels were higher in patients with fatal disease than in patients with nonfatal disease during the initial clinical course of SFTS. In addition, we found that IL-6 and IL-10 levels, rather than viral load and neutralizing antibody titers, in patients with an SFTSV infection strongly correlated with outcomes (for severe disease with an ultimate outcome of recovery or death).
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Authors | Jeong Rae Yoo, Tae-Jin Kim, Sang Taek Heo, Kyung-Ah Hwang, Hyunjoo Oh, TaeHong Ha, Hye Kyung Ko, Seungjae Baek, Ju Eun Kim, Jun Hyeong Kim, Jiin Lee, Min Ji Kang, Mi Soo Yoo, Jung Mogg Kim, Kyung-Mi Lee, Keun Hwa Lee |
Journal | Frontiers in immunology
(Front Immunol)
Vol. 12
Pg. 711847
( 2021)
ISSN: 1664-3224 [Electronic] Switzerland |
PMID | 34484214
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021 Yoo, Kim, Heo, Hwang, Oh, Ha, Ko, Baek, Kim, Kim, Lee, Kang, Yoo, Kim, Lee and Lee. |
Chemical References |
- Antibodies, Neutralizing
- Antibodies, Viral
- Cytokines
- IL10 protein, human
- IL6 protein, human
- Interleukin-6
- Interleukin-10
- L-Lactate Dehydrogenase
- Aspartate Aminotransferases
- Alanine Transaminase
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Topics |
- Aged
- Aged, 80 and over
- Alanine Transaminase
(blood)
- Antibodies, Neutralizing
(blood, immunology)
- Antibodies, Viral
(blood, immunology)
- Aspartate Aminotransferases
(blood)
- Cytokines
(blood)
- Dyspnea
(etiology)
- Female
- Humans
- Interleukin-10
(blood, physiology)
- Interleukin-6
(blood, physiology)
- L-Lactate Dehydrogenase
(blood)
- Male
- Middle Aged
- Multiple Organ Failure
(etiology, mortality)
- Phlebovirus
(immunology)
- Republic of Korea
(epidemiology)
- Severe Fever with Thrombocytopenia Syndrome
(blood, immunology, mortality, virology)
- Treatment Outcome
- Viral Load
- Viremia
(blood, immunology, mortality)
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