Reduced Sensitivity to Thyroid Hormone Is Associated with Diabetes and Hypertension.

Abstract

CONTEXT:

Recently, reduced sensitivity to thyroid hormone as a more common finding in the general population and its possible association with metabolic parameters has been the focus of attention.

OBJECTIVE:

The objective was to evaluate the cross-sectional association of thyroid hormone sensitivity with diabetes, metabolic syndrome (MetS), and its components.

METHODS:

The study included a Tehranian representative sample of 5124 subjects aged ≥20 years participating in the Tehran Thyroid Study (2008-2011). Body weight, waist circumference, and blood pressure (BP) were measured, and serum concentrations of lipids and lipoproteins, fasting blood glucose, insulin, free thyroxine (fT4), and thyrotropin (TSH) were assayed. Thyroid hormone resistance was calculated by the Thyroid Feedback Quantile-based Index (TFQI) and Iranian-referenced Parametric TFQI (PTFQI) and compared with 2 other indices: Thyrotroph T4 Resistance Index (TT4RI) and TSH Index.

RESULTS:

TFQI was significantly associated with high BP MetS criterion (OR = 1.14, 95% CI: 1.06, 1.23) and diabetes mellitus (OR = 1.16, 95% CI: 1.04, 1. 30, P = .009) in euthyroid subjects after adjusting for age, sex, smoking, physical activity, body mass index, and Homeostasis Model Assessment Index for Insulin Resistance. TFQI was not associated with new-onset diabetes contrary to known diabetes in subgroup analysis. The results were similar for PTFQI. TSHI (OR = 1.22, 95% CI: 1.08, 1.38, P = .001) and TT4RI (OR = 1.08, 95% CI: 1.01, 1.16, P < .001) were associated only with high BP in euthyroid subjects.

CONCLUSION:

The new TFQI index seems to be the indicator of reduced sensitivity to thyroid hormone most suitable to associate its population variations with diabetes and hypertension in euthyroid subjects; however, interpretation for diabetes should be concerned with cautions, necessitating future studies.

• Authors: Ladan Mehran, Negar Delbari, Atieh Amouzegar, Mitra Hasheminia, Maryam Tohidi, Fereidoun Azizi
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 107 Issue 1 Pg. 167-176 (01 01 2022) ISSN: 1945-7197 [Electronic] United States
• PMID: 34480566 (Publication Type: Journal Article, Multicenter Study, Observational Study)
• Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Thyroid Hormones

Topics

• Adolescent
• Adult
• Aged
• Child
• Child, Preschool
• Cross-Sectional Studies
• Diabetes Mellitus (epidemiology, metabolism)
• Female
• Humans
• Hypertension (epidemiology, metabolism)
• Iran (epidemiology)
• Male
• Metabolic Syndrome (epidemiology, metabolism)
• Middle Aged
• Risk Factors
• Thyroid Function Tests
• Thyroid Gland
• Thyroid Hormone Resistance Syndrome (diagnosis, epidemiology, metabolism)
• Thyroid Hormones (metabolism)
• Young Adult