Abstract | BACKGROUND: METHODS: High glucose/high fat (HG/HF) and hypoxia culture condition were established to mimic diabetic condition. After administration of AS-IV to H9c2 myocytes, the cell apoptosis, viability, and activation of mitogen-activated protein kinase (MAPK) signaling pathways were detected. MI was induced in streptozotocin-induced diabetic mice. After administration of AS-IV to mice, cardiac function, cardiac fibrosis, inflammation, and activation of MAPK signaling pathway were detected. RESULTS:
Astragaloside IV treatment significantly inhibited HG/HF and hypoxia-induced apoptosis of H9c2. AS-IV inhibited activation of JNK and p38 signaling pathway while promoting the activation of EKR signaling pathway. AS-IV treatment rescued cardiac function, suppressed cardiac fibrosis and inflammation, and differently regulated the activation of MAPK signaling pathways. CONCLUSION:
Astragaloside IV prevented apoptosis and restored cardiac function in MI, which may be due to the regulation of MAPK signaling pathway in diabetes.
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Authors | Chuang Sun, Guangwei Zeng, Tingting Wang, He Ren, Huixian An, Cheng Lian, Jing Liu, Li Guo, Wei Li |
Journal | Frontiers in cell and developmental biology
(Front Cell Dev Biol)
Vol. 9
Pg. 671255
( 2021)
ISSN: 2296-634X [Print] Switzerland |
PMID | 34395418
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Sun, Zeng, Wang, Ren, An, Lian, Liu, Guo and Li. |