Effect of multimodal analgesia on perioperative insulin resistance in patients with colon cancer.

Abstract

BACKGROUND:

High risk of post-surgery complications have always been related with uncontrolled blood glucose, while the relationship between blood glucose and analgesia has not been compared on radical resection of colon cancer. The aim of this study is to investigate the effects of multimodal analgesia on perioperative insulin resistance in patients undergoing radical resection of colon cancer.

METHODS:

Sixty patients with colon cancer scheduled for radical resection surgery were equally divided into two groups randomly, the control group (TAP group) received general anesthesia and the transversus abdominis plane block analgesia, and the experimental group (GEA group) received extra epidural anesthesia. The analgesic efficacy was evaluated with visual analog scale (VAS). Insulin resistance indicators like fasting plasma glucose (FPG), resistin (RESIS), fasting insulin (FINS), homeostasis model assessment (HOMA) levels, and inflammation indicator interleukin-6 (IL-6) were evaluated during the surgery.

RESULTS:

IL-6 increase was significant in the TAP group than that in GEA group (P < 0.01). The insulin resistance increased significantly in TAP group than that in GEA group including HOMA (P < 0.05) and FPG (P < 0.05). There was no significant difference in RESIS levels and VAS scores in the two groups.

CONCLUSION:

Epidural anesthesia leads to less inflammation in radical resection of colon cancer and the insulin level and insulin resistance increased after the surgeries based on FINS and HOMA..

• Authors: Yuxuan Zhang, Tao Su, Ruixuan Li, Qiang Yan, Wen Zhang, Guiping Xu
• Journal: Indian journal of cancer (Indian J Cancer) 2021 Jul-Sep Vol. 58 Issue 3 Pg. 349-354 ISSN: 1998-4774 [Electronic] India
• PMID: 34380842 (Publication Type: Journal Article, Randomized Controlled Trial)

Topics

• Analgesia (adverse effects)
• Colonic Neoplasms (drug therapy)
• Female
• Humans
• Insulin Resistance (physiology)
• Male
• Middle Aged
• Nerve Block (adverse effects)
• Perioperative Period (methods)