Serum C-Reactive Protein-to-Body Mass Index Ratio Predicts Overall Survival in Patients With Resected Colorectal Cancer.

Abstract

BACKGROUND AND PURPOSE:

Systemic inflammation and nutritional status have been shown to be associated with the prognosis of colorectal cancer. The purpose of this study was to evaluate the impact of the serum C-reactive protein-to-body mass index ratio on the prognosis of patients with curatively resected colorectal cancer.

METHODS:

We conducted a retrospective analysis of a database of 2,471 eligible patients with colorectal cancer who underwent curative resection at our hospital between 2004 and 2019. The optimal cut-off for CPR-to-BMI ratio was determined using maximally selected rank statistics. Patients were divided into 2 groups according to the cut-off value of the serum C-reactive protein-to-body mass index ratio. Kaplan-Meier curves and Cox regression analysis were used to compare overall survival. A two-sided P-value < 0.05 was considered statistically significant.

RESULTS:

The proportion of patients with a high C-reactive protein-to-body mass index ratio increased with increasing age, male sex, right-sided colon cancer, poorly differentiated tumors, advanced-stage disease, local/distant metastases, tumor-node-metastasis stage, and microsatellite instability. In subgroup analysis according to tumor-node-metastasis stage, the overall survival of the high C-reactive protein-to-body mass index ratio group was significantly shorter than that of the low C-reactive protein-to-body mass index ratio group (P < 0.001). Multivariate analysis identified age, differentiation, tumor-node-metastasis stage, carcinoembryonic antigen level, and the C-reactive protein-to-body mass index ratio as independent poor prognostic factors for overall survival.

CONCLUSIONS:

The C-reactive protein-to-body mass index ratio predicts the prognosis of patients with curatively resected colorectal cancer and is an independent risk factor for overall survival in patients with colorectal cancer.

• Authors: Lingxu Huang, Jungang Liu, Xiaoliang Huang, Chunyin Wei, Xianwei Mo, Huage Zhong, Yongsheng Meng, Hao Lai, Lihua Zhang, Dingyu Liang, Haizhou Liu, Weizhong Tang
• Journal: Technology in cancer research & treatment (Technol Cancer Res Treat) 2021 Jan-Dec Vol. 20 Pg. 15330338211037418 ISSN: 1533-0338 [Electronic] United States
• PMID: 34338056 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinoembryonic Antigen
• C-Reactive Protein

Topics

• Adult
• Age Factors
• Aged
• Body Mass Index
• C-Reactive Protein (metabolism)
• Carcinoembryonic Antigen (blood)
• Colorectal Neoplasms (blood, pathology, physiopathology, surgery)
• Female
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Neoplasm Grading
• Neoplasm Staging
• Nutritional Status
• Odds Ratio
• Prognosis
• Proportional Hazards Models
• Retrospective Studies
• Survival Rate