High-dose intravenous immunoglobulins might modulate inflammation in COVID-19 patients.

Abstract

The use of high-dose of intravenous immunoglobulins (IVIGs) as immunomodulators for the treatment of COVID-19-affected individuals has shown promising results. IVIG reduced inflammation in these patients, who progressively restored respiratory function. However, little is known about how they may modulate immune responses in COVID-19 individuals. Here, we have analyzed the levels of 41 inflammatory biomarkers in plasma samples obtained at day 0 (pretreatment initiation), 3, 7, and 14 from five hospitalized COVID-19 patients treated with a 5-d course of 400 mg/kg/d of IVIG. The plasmatic levels of several cytokines (Tumor Necrosis Factor, IL-10, IL-5, and IL-7), chemokines (macrophage inflammatory protein-1α), growth/tissue repairing factors (hepatic growth factor), complement activation (C5a), and intestinal damage such as Fatty acid-binding protein 2 and LPS-binding protein showed a progressive decreasing trend during the next 2 wk after treatment initiation. This trend was not observed in IVIG-untreated COVID-19 patients. Thus, the administration of high-dose IVIG to hospitalized COVID-19 patients may improve their clinical evolution by modulating their hyperinflammatory and immunosuppressive status.

• Authors: María Luisa Rodríguez de la Concepción, Erola Ainsua-Enrich, Esteban Reynaga, Carlos Ávila-Nieto, Jose Ramón Santos, Silvia Roure, Lourdes Mateu, Roger Paredes, Jordi Puig, Juan Manuel Jimenez, Nuria Izquierdo-Useros, Bonaventura Clotet, María Luisa Pedro-Botet, Jorge Carrillo
• Journal: Life science alliance (Life Sci Alliance) Vol. 4 Issue 9 (09 2021) ISSN: 2575-1077 [Electronic] United States
• PMID: 34321327 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021 Rodríguez de la Concepción et al.

Chemical References

• Biomarkers
• Chemokines
• Cytokines
• Immunoglobulins
• Immunoglobulins, Intravenous

Topics

• Administration, Intravenous
• Adult
• Aged
• Biomarkers (blood)
• COVID-19 (blood, immunology, therapy, virology)
• Chemokines (blood)
• Cytokines (blood)
• Female
• Humans
• Immunity (immunology)
• Immunoglobulins (immunology, therapeutic use)
• Immunoglobulins, Intravenous (immunology, therapeutic use)
• Inflammation (blood, therapy, virology)
• Male
• Middle Aged
• SARS-CoV-2 (isolation & purification)