Abstract | INTRODUCTION: METHODS: A cross-sectional study of Thai children with obesity (5 to 15 years old) versus age- and sex-matched, nonobese controls was conducted. A total of 63 children with obesity and 27 controls were enrolled. Complete blood count, serum iron, ferritin, transferrin saturation, and total iron binding capacity were analyzed. Serum hepcidin-25 was assayed using a hepcidin ELISA Kit (Human Hepc25). RESULTS: There were 63 children with obesity, the median age (IQR) being 10 (9-13) years, and 27 controls. The median (IQR) BMI-SDS of the obese group was 2.3 (2.0-2.6) vs. -0.5 ((-1.3)-0.4) of the control group. ID was diagnosed in 27 children in the obese group (42.9%); 4 of the children with obesity and ID had anemia. Serum hepcidin-25 levels of the children with ID vs. without ID in the obese group were not significantly different (median (IQR) 25 (12.9-49.2) and 26.4 (12.6-43.6), respectively) but both of them were significantly higher than controls (19.7 (8.3-25.5) ng/ml, p = 0.04). BMI-SDS was positively correlated with hepcidin-25 (r = 0.28, p = 0.001). CONCLUSION: Prevalence of iron deficiency in Thai children with obesity and serum hepcidin-25 was higher than controls. Further study in a larger population, preferably with interventions such as weight loss program, is warranted to clarify this association.
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Authors | Ekkarit Panichsillaphakit, Orapa Suteerojntrakool, Chitsanu Pancharoen, Issarang Nuchprayoon, Sirinuch Chomtho |
Journal | Journal of nutrition and metabolism
(J Nutr Metab)
Vol. 2021
Pg. 9944035
( 2021)
ISSN: 2090-0724 [Print] United States |
PMID | 34258058
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Ekkarit Panichsillaphakit et al. |