Prospective, observational study.
SETTING: Closed university-affiliated intensive care unit.
PATIENTS: We enrolled consecutive patients >18 yrs of age expected to be in intensive care unit for ≥24 hours.
INTERVENTIONS: None.
MEASUREMENTS AND MAIN RESULTS: The score of Montreal Cognitive Assessment (MoCA) less than 26 was defined as
cognitive impairment at hospital discharge and short-term post-ICU
cognitive impairment was diagnosed in 185 of 409 assessed patients (45.2%). According to univariate analysis, age, years of education, occupation, past medical history, main ICU diagnosis, Acute Physiology and Chronic Evaluation Scoring System (APACHE II) score, Sequential Organ Failure Assessment (SOFA) score, Charlson comorbidity index, ICU
length-of-stay (LOS), total hospital LOS, sedation, vasoactive agents, muscle relaxants,
mechanical ventilation and duration of
mechanical ventilation, constraints, early active mobilisation,
hypoxemia, frequency and severity of
delirium, blood pressure, rescue experience, and
infection were significant predictors of post-ICU
cognitive impairment. Multivariate analysis results showed that the frequency and severity of
delirium, and advanced age were risk factors of post-ICU
cognitive impairment; high years of education and early active mobilisation were protective factors.
CONCLUSIONS: