Abstract | BACKGROUND & AIMS: METHODS: RESULTS: We observed attenuated disease activity in mice deficient for Saa1/2 as evidenced by decreased weight loss, increased stool consistency, decreased rectal bleeding, and decreased colitis-associated tissue damage. Macrophage infiltration, including CD206+ M2-like macrophages, also was attenuated in SAA knockout mice, while levels of interleukin 4, interleukin 10, and tumor necrosis factor-ɑ were decreased in the distal colon. Mice deficient for SAA also showed a decreased tumor burden, and tumors were found to have increased apoptotic activity coupled with decreased expression for markers of proliferation. CONCLUSION:
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Authors | Tanja A Davis, Daleen Conradie, Preetha Shridas, Frederick C de Beer, Anna-Mart Engelbrecht, Willem J S de Villiers |
Journal | Cellular and molecular gastroenterology and hepatology
(Cell Mol Gastroenterol Hepatol)
Vol. 12
Issue 4
Pg. 1329-1341
( 2021)
ISSN: 2352-345X [Electronic] United States |
PMID | 34217896
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Protein Isoforms
- Serum Amyloid A Protein
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Topics |
- Animals
- Biomarkers
- Cell Transformation, Neoplastic
(genetics, metabolism)
- Colitis-Associated Neoplasms
(etiology, metabolism, pathology)
- Disease Models, Animal
- Disease Susceptibility
- Immunohistochemistry
- Intestinal Mucosa
(metabolism, pathology)
- Macrophages
(metabolism, pathology)
- Mice
- Mice, Knockout
- Protein Isoforms
- Serum Amyloid A Protein
(genetics, metabolism)
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