Effects of acyl-coenzyme A binding protein (ACBP)/diazepam-binding inhibitor (DBI) on body mass index.
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| Abstract |
In mice, the plasma concentrations of the appetite-stimulatory and autophagy-inhibitory factor acyl-coenzyme A binding protein (ACBP, also called diazepam-binding inhibitor, DBI) acutely increase in response to starvation, but also do so upon chronic overnutrition leading to obesity. Here, we show that knockout of Acbp/Dbi in adipose tissue is sufficient to prevent high-fat diet-induced weight gain in mice. We investigated ACBP/DBI plasma concentrations in several patient cohorts to discover a similar dual pattern of regulation. In relatively healthy subjects, ACBP/DBI concentrations independently correlated with body mass index (BMI) and age. The association between ACBP/DBI and BMI was lost in subjects that underwent major weight gain in the subsequent 3-9 years, as well as in advanced cancer patients. Voluntary fasting, undernutrition in the context of advanced cancer, as well as chemotherapy were associated with an increase in circulating ACBP/DBI levels. Altogether, these results support the conclusion that ACBP/DBI may play an important role in body mass homeostasis as well as in its failure.
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| Authors | Adrien Joseph, Hui Chen, Gerasimos Anagnostopoulos, Léa Montégut, Antoine Lafarge, Omar Motiño, Maria Castedo, Maria Chiara Maiuri, Karine Clément, Safae Terrisse, Anne Laure Martin, Ines Vaz-Luis, Fabrice Andre, Franziska Grundler, Françoise Wilhelmi de Toledo, Frank Madeo, Laurence Zitvogel, François Goldwasser, Benoit Blanchet, Frédéric Fumeron, Ronan Roussel, Isabelle Martins, Guido Kroemer |
| Journal | Cell death & disease (Cell Death Dis) Vol. 12 Issue 6 Pg. 599 (06 09 2021) ISSN: 2041-4889 [Electronic] England |
| PMID | 34108446 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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