Abstract | BACKGROUND: The 14q32 cluster is among the largest polycistronic miRNA clusters. miRNAs encoded here have been implicated in tumorigenesis of multiple organs including endocrine glands. METHODS: Critical review of miRNA studies performed in endocrine tumors have been performed. The potential relevance of 14q32 miRNAs through investigating their targets, and integrating the knowledge provided by literature data and bioinformatics predictions have been indicated. RESULTS: CONCLUSIONS: 14q32 miRNAs have a significant role in the tumorigenesis of endocrine organs. Regarding their stable expression in the circulation of healthy individuals, further investigation of 14q32 miRNAs could provide a potential for use as biomarkers (diagnostic or prognostic) in endocrine neoplasms.
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Authors | Lilla Krokker, Attila Patócs, Henriett Butz |
Journal | Genes
(Genes (Basel))
Vol. 12
Issue 5
(05 08 2021)
ISSN: 2073-4425 [Electronic] Switzerland |
PMID | 34066712
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Chromosomes, Human, Pair 14
(genetics)
- Endocrine Gland Neoplasms
(genetics, metabolism)
- Gene Expression Regulation, Neoplastic
- Genetic Loci
- Humans
- MicroRNAs
(genetics, metabolism)
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