Abstract | BACKGROUND/AIMS: METHODS: AP patients admitted ≤ 48 h after abdominal pain onset were retrospectively analyzed. Patients were stratified by pre-existing diabetes and stress hyperglycemia was defined using stratified BG levels for non-diabetes and diabetes with clinical outcomes compared. RESULTS: There were 967 non-diabetic and 114 diabetic (10.5%) patients met the inclusion criteria and the clinical outcomes between these two groups were not significantly different. In non-diabetes, the cut-off BG level of ≥ 180 mg/dl was selected to define stress hyperglycemia with an 8.8-fold higher odds ratio for persistent organ failure (POF) (95% CI 5.4-14.3; P < 0.001). For diabetes, ≥ 300 mg/dl was selected with a 7.5-fold higher odds ratio for POF (95% CI 1.7-34.3; P = 0.009). In multivariable logistic regression, stress hyperglycemia was independently associated with POF, acute necrotic collection, major infection and mortality. The combination of BG and systemic inflammatory response syndrome (SIRS) score in predicting POF was better than SIRS or Glasgow score alone. CONCLUSIONS: This study identifies a cut-off BG level of ≥ 180 mg/dl and ≥ 300 mg/dl was optimal to define stress hyperglycemia for non-diabetic and diabetic AP patients, respectively. There was a significant relationship between stress hyperglycemia and adverse clinical outcomes.
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Authors | Xinmin Yang, Ruwen Zhang, Tao Jin, Ping Zhu, Linbo Yao, Lan Li, Wenhao Cai, Rajarshi Mukherjee, Dan Du, Xianghui Fu, Jing Xue, Reynaldo Martina, Tingting Liu, Sayali Pendharkar, Anthony R Phillips, Vikesh K Singh, Robert Sutton, John A Windsor, Lihui Deng, Qing Xia, Wei Huang |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 67
Issue 5
Pg. 1879-1889
(05 2022)
ISSN: 1573-2568 [Electronic] United States |
PMID | 33939149
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021. The Author(s). |
Chemical References |
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Topics |
- Acute Disease
- Blood Glucose
- Diabetes Mellitus
- Humans
- Hyperglycemia
(complications, epidemiology)
- Pancreatitis
(complications)
- Retrospective Studies
- Systemic Inflammatory Response Syndrome
(diagnosis, epidemiology)
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