Phase Angle as an Easy Diagnostic Tool of Meta-Inflammation for the Nutritionist.
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| Abstract |
Phase angle (PhA), a noninvasive bioimpedance marker, is a useful tool for nutritional screening in several diseases. C-reactive protein (CRP), a strong risk factor for metabolic and cardiovascular diseases, is a commonly used biomarker of meta-inflammation. As both PhA and CRP are influenced by age, BMI, and nutritional status, and exhibit a clear sex dimorphism, we examined the association between PhA and CRP levels in 1855 subjects (680 males and 1175 females), aged 18-59 years, with BMIs ranging from 19.5 to 69.4 kg/m2, stratified according to sex. PhA values and CRP levels were significantly lower in females than males (p < 0.001), while the adherence to the Mediterranean diet (MD) was lower in males compared to females (p < 0.001). After adjusting for age, physical activity, BMI, waist circumference, and adherence to the MD, PhA remained negatively associated with CRP levels in both genders (p < 0.001). In the ROC analysis, PhA ≤ 5.5° in males and ≤5.4° in females were the threshold values predicting increased hs-CRP levels. These results suggested that PhA might represent a valid predictor of CRP levels in both sexes regardless of body weight and adherence to the MD, which avoids the collection of blood sampling and expensive biochemical assays.
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| Authors | Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Daniela Laudisio, Giulia de Alteriis, Chiara Graziadio, Annamaria Colao, Silvia Savastano |
| Journal | Nutrients (Nutrients) Vol. 13 Issue 5 (Apr 24 2021) ISSN: 2072-6643 [Electronic] Switzerland |
| PMID | 33923291 (Publication Type: Journal Article) |
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