Hemicraniectomy and externalized ventricular drain placement in a pediatric patient with myelin oligodendrocyte glycoprotein-associated tumefactive demyelinating disease.

Abstract

BACKGROUND:

Acquired demyelination of the central nervous system in children can manifest as multiple sclerosis, neuromyelitis optica, myelin oligodendrocyte glycoprotein (MOG)-associated demyelination, or as an acute monophasic illness without serum antibodies. Rarely do patients with demyelinating disease need surgical intervention for fulminant crises.

CASE:

We report a case of anti-MOG antibody-related tumefactive demyelination in a 10-year-old female who required urgent hemicraniectomy and external ventricular drain placement for progressive white matter edema with obstructive hydrocephalus, subfalcine, and transtentorial herniation.

• Authors: Saurabh Sinha, Brenda Banwell, Alexander Tucker, Phillip B Storm, Jimmy Huh, Shih-Shan Lang
• Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (Childs Nerv Syst) Vol. 38 Issue 1 Pg. 185-189 (01 2022) ISSN: 1433-0350 [Electronic] Germany
• PMID: 33796928 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Chemical References

• Autoantibodies
• Myelin-Oligodendrocyte Glycoprotein

Topics

• Autoantibodies
• Child
• Drainage
• Female
• Humans
• Hydrocephalus (etiology, surgery)
• Myelin-Oligodendrocyte Glycoprotein
• Neuromyelitis Optica