Micro Composite Palmitoylethanolamide/Rutin Reduces Vascular Injury through Modulation of the Nrf2/HO-1 and NF-kB Pathways.

Abstract

BACKGROUND:

Vascular remodeling processes induced by acute and chronic injuries are characterized by inflammation and oxidative stress. In arteriosclerosis, atherosclerosis, and restenosis, the progression of neointimal hyperplasia is a key event of vascular damage.

OBJECTIVE:

Our study was aimed to investigate the inflammation and oxidative stress development during vascular impairment and the potential efficacy of treatment of new micro composite N-palmitoylethanolamine/Rutin at a ratio of 1:1 (PEA/RUT). The anti-inflammatory effects of Palmitoylethanolamide (PEA) are well known. Rutin has important pharmacological actions, including antioxidant and vasoprotective.

METHODS:

As a model of vascular injury, we used the complete ligature of the left carotid artery for fourteen days and administered PEA/RUT at the dose of 10 mg/Kg.

RESULTS:

This study demonstrated that after fourteen days of carotid ligation, there is a substantial structural change in the vessel morphology, with inflammatory cell infiltration and reactive oxygen species production. PEA/RUT administration reduced change in vascular morphology, cytokines like monocyte chemoattractant protein-1 (MCP-1) and adhesion molecules expression like intercellular adhesion molecules-1 (ICAM-1), proinflammatory cytokines production (IL-1 β, IL-6 and TNF- α), oxidative and nitrosative stress (nitrotyrosine and PARP expression and NRF2 pathway).

CONCLUSION:

Our data clearly demonstrate the beneficial effect of PEA/RUT administration in reducing inflammation, oxidative stress, and vascular damage.

• Authors: Roberta Fusco, Rosalba Siracusa, Enrico Gugliandolo, Alessio Filippo Peritore, Ramona D'Amico, Marika Cordaro, Rosalia Crupi, Daniela Impellizzeri, Chiara Gomiero, Salvatore Cuzzocrea, Rosanna Di Paola
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 28 Issue 30 Pg. 6287-6302 ( 2021) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 33781184 (Publication Type: Journal Article)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Amides
• Ethanolamines
• Membrane Proteins
• NF-E2-Related Factor 2
• NF-kappa B
• Palmitic Acids
• Rutin
• palmidrol
• Heme Oxygenase-1
• Hmox1 protein, mouse

Topics

• Amides (pharmacology)
• Animals
• Ethanolamines (pharmacology)
• Heme Oxygenase-1
• Male
• Membrane Proteins
• Mice
• NF-E2-Related Factor 2
• NF-kappa B
• Palmitic Acids (pharmacology)
• Rutin (pharmacology)
• Vascular System Injuries