Arteriosclerosis

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2821 relevant articles (53 outcomes, 255 trials/studies) found for this Disease

Description: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.

Also Known As:

Arterioscleroses

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 20552

Vascular Diseases: 7633

Arterial Occlusive Diseases: 1111

Arteriosclerosis: 2821

Atherosclerosis: 32140

Coronary Artery Disease: 19596

Intermittent Claudication: 1078

Arteriosclerosis Obliterans: 323

Intracranial Arteriosclerosis: 249

Arteriolosclerosis: 61

Monckeberg Medial Calcific Sclerosis: 1

Related Diseases

1.	Hypertension (High Blood Pressure)
2.	Infection
3.	Inflammation
4.	Stroke (Strokes)
5.	Atrophy

Experts

1.	Wood, Kathryn J: 8 articles (08/2008 - 01/2002)
2.	Ensminger, Stephan M: 7 articles (08/2008 - 01/2002)
3.	Spriewald, Bernd M: 6 articles (08/2008 - 01/2002)
4.	Rozing, Jan: 6 articles (08/2007 - 03/2002)
5.	Hillebrands, Jan-Luuk: 6 articles (08/2007 - 03/2002)
6.	Morris, P J: 6 articles (07/2001 - 06/2000)
7.	Wood, K J: 6 articles (07/2001 - 06/2000)
8.	Ensminger, S M: 6 articles (07/2001 - 06/2000)
9.	Lemström, Karl B: 5 articles (04/2007 - 02/2002)
10.	Koskinen, Petri K: 5 articles (04/2007 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Arteriosclerosis:

1.	Lipoproteins (Lipoprotein)IBA 01/01/1988 - "Endurance training induces alterations in the lipoprotein metabolism which could be useful for protection against arteriosclerosis. " 04/01/1957 - "[Diagnosis & evaluation of therapeutic measures in arteriosclerosis; paper electrophoretic determination of lipoproteins for the study of fat metabolic disorders & determination of pulse wave rate as a measure of vascular elasticity.]" 09/22/2004 - "The oxidative modification of low-density lipoprotein (LDL) plays an important role in the genesis of arteriosclerosis. " 06/01/2004 - "High density lipoprotein (HDL) is one of the most important independent protective factors for the arteriosclerosis which underlies CHD. " 01/01/2004 - "Lipoprotein oxidation products and arteriosclerosis: theory and methods with applicability to the clinical chemistry laboratory." Order ALL the reference details at left...
2.	CholesterolIBA 07/01/1989 - "The SEA strain of Japanese quail appears to be a practical model for the study of arteriosclerosis; fish oil reduces the severity of disease in these birds when fed a high cholesterol diet." 03/01/2005 - "Effect of cholesterol lowering and cardiovascular risk factors on the progression of aortoiliac arteriosclerosis: a quantitative cineangiography study." 04/01/1996 - "Our basis of the described theories of arteriosclerosis and cholesterol the multiple uneffective studies with reduction in levels of plasmalipids must be provided. " 07/01/1992 - "The aim of this controlled study was to give an answer to the question, whether cholesterol level in blood is as important for local cholesterol accumulation in the lens as it is for the mechanism of arteriosclerosis. " 01/01/1972 - "[Morphological and biochemical studies on the different development of cholesterol-induced aortic and coronary artery arteriosclerosis in rabbits]" Order ALL the reference details at left...
3.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 09/24/1996 - "Whether low-dose aspirin is equally effective for reducing progression of arteriosclerosis in the cerebrovascular and in the peripheral vessels is questionable. " 08/01/2009 - "Generalized estimating equations were used to assess whether plasma levels of haemostatic markers were associated with measures of arteriosclerosis, after adjustment for conventional risk factors and medication (statin, aspirin and oestrogen) use. " 11/01/1988 - "[Evaluation of the effect of polopirin S on platelet adhesiveness in chronic peripheral circulatory failure in arteriosclerosis]" 07/01/1985 - "We concluded that: 1) aspirin markedly reduced the microscopic and macroscopic arteriosclerosis in Groups B and C; 2) aspirin in Group B not only arrested further development but also permitted resolution of arteriosclerosis while the arteries were still being injured." 07/01/1985 - "The ability of aspirin to block arteriosclerosis that developed in response to chronic, low-level injury to pulmonary arteries was evaluated in 21 dogs during their 1-year infection with Dirofilaria immitis. " Order ALL the reference details at left...
4.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 03/27/2000 - "BACKGROUND: Inducible nitric oxide synthase (iNOS) is up-regulated in rejecting allografts and is protective against allograft arteriosclerosis; it suppresses neointimal smooth muscle cell accumulation and inhibits adhesion of platelets and leukocytes to the endothelium. " 11/06/2001 - "BACKGROUND: Inducible nitric oxide synthase (iNOS, or NOS2) reduces the severity of accelerated graft arteriosclerosis (AGA) in transplanted organs, although the precise mechanism is unclear. " 09/18/2001 - "BACKGROUND: Inducible nitric oxide synthase (iNOS) is expressed and is functionally active in the presence of transplant arteriosclerosis. " 12/01/1999 - "Role of inducible nitric oxide synthase in transplant arteriosclerosis." 10/15/1997 - "Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis." Order ALL the reference details at left...
5.	pioglitazone (Actos)FDA Link 01/01/2006 - "Pioglitazone was also effective in reducing some measures of cardiovascular risk and arteriosclerosis. " 01/01/2006 - "Pioglitazone was also effective in reducing some measures of cardiovascular risk and arteriosclerosis. " 08/01/2005 - "Pioglitazone improves aortic wall elasticity in a rat model of elastocalcinotic arteriosclerosis." 05/01/2005 - "Effect of pioglitazone on arteriosclerosis in comparison with that of glibenclamide." 11/01/2002 - "We examined the effects of pioglitazone (a PPARgamma ligand) in this rat model to determine whether PPARgamma activation with pioglitazone inhibits arteriosclerosis by its indirect effects on metabolic conditions or by direct effects on the cells participating to the pathogenesis of arteriosclerosis. " Order ALL the reference details at left...
6.	Heparin (Liquaemin)FDA LinkGeneric 06/01/1954 - "[Action of heparin in arteriosclerosis: clinical and experimental study.]" 09/01/2005 - "Exercise after heparin administration: new therapeutic program for patients with-option arteriosclerosis oblitrans." 01/01/1980 - "Continuous heparin anticoagulation in patients with arteriosclerosis and arterial emboli." 08/01/1976 - "[Effect of heparin electrophoresis on myocardial function in patients with arteriosclerosis]" 09/01/1967 - "[On the interrelationship between the level of free heparin and blood basophil count in experimental arteriosclerosis]" Order ALL the reference details at left...
7.	LDL CholesterolIBA 04/01/2009 - "Purely mechanically-induced changes in LDL-cholesterol may be one mechanism that contributes to the activation of CD8 cells and, as a consequence, the emergence of arteriosclerosis." 10/01/1992 - "The MDA level significantly correlated positively to total- or LDL-cholesterol level and urinary K/Cr, thus MDA level seemed to be a risk factor of arteriosclerosis. " 01/01/1991 - "Of equal, or even greater importance are the levels of the "bad cholesterol" LDL that produces arteriosclerosis. " 01/01/1980 - "[HDL/LDL-cholesterol, arteriosclerosis and age (author's transl)]" 11/01/2004 - "These results suggested that the deep seawater was useful for the prevention of hyperlipidemia and arteriosclerosis compared to the surface seawater, and it was found that reduction of the LDL cholesterol level and enhancement of GPx activity were involved in its effects." Order ALL the reference details at left...
8.	rho-Associated KinasesIBA 04/01/2007 - "In a series of experimental and clinical studies, we have demonstrated that Rho-kinase-mediated pathway plays an important role in various cellular functions, not only in vascular smooth muscle hyperconstriction but also in actin cytoskeleton organization, cell adhesion and motility, cytokinesis, and gene expression, all of which may be involved in the pathogenesis of arteriosclerosis. " 08/01/2004 - "Recent studies have demonstrated that upregulated Rho-kinase plays an important role in the pathogenesis of arteriosclerosis and vasospasm in both animals and humans. " 08/01/2004 - "Since inflammatory mechanisms have been implicated in the pathogenesis of arteriosclerosis and vasospasm, we examined whether inflammatory stimuli upregulate Rho-kinase in vitro and in vivo. " 05/01/2002 - "The Rho/Rho-kinase pathway is involved in the pathogenesis of hypertension, vasospasm and arteriosclerosis, and is a potent target of new therapies for these diseases." 03/01/2002 - "Accumulating evidence has demonstrated that the Rho/Rho-kinase-mediated pathway plays an important role in various cellular functions, not only in vascular smooth muscle contraction but also in actin cytoskeleton organization, cell adhesion and motility, cytokinesis, and gene expressions, all of which may be involved in the pathogenesis of arteriosclerosis/atherosclerosis. " Order ALL the reference details at left...
9.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 06/22/1964 - "[CLINICAL STUDIES ON THE EFFECT OF UNSATURATED FATTY ACIDS ON ARTERIOSCLEROSIS.]" 08/01/2007 - "BACKGROUND: Consumption of polyunsaturated fatty acids (PUFA) improves the lipid metabolism of diabetics, leading to prevents of arteriosclerosis. " 10/29/1984 - "[Polyunsaturated fatty acids in the prevention of arteriosclerosis]" 09/14/1973 - "[Unsaturated fatty acids and arteriosclerosis]" 12/02/1963 - "[PROTECTIVE EFFECT OF UNSATURATED FATTY ACIDS ON DEGENERATIVE CHANGES IN THE LIVER AND KIDNEY GLOMERULI IN EXPERIMENTAL ARTERIOSCLEROSIS.]" Order ALL the reference details at left...
10.	Pentoxifylline (Trental)FDA LinkGeneric 07/01/1990 - "Ten patients with chronic occlusive arteriosclerosis received single oral doses of 100, 200, 400, 800, and 1200 mg pentoxifylline in a single-blind, placebo-controlled study. " 01/01/1987 - "A study was carried out in 127 patients (94 males and 33 females) presenting with arteriosclerosis (88 patients) or diabetic vasculopathy (39 patients) in different stages of severity (Fontaine) to assess the effectiveness and tolerance of treatment with high doses of pentoxifylline. " 11/01/1987 - "[Effect of treatment with trental on indicators of peripheral hemodynamics and blood lipid level in patients with arteriosclerosis of the lower extremities]" 10/01/1982 - "[Trental treatment of microcirculatory disorders in diabetes mellitus and arteriosclerosis]" 07/01/1997 - "According to a number of studies pentoxifylline and naftidrofuryl may delay the progression of arteriosclerosis. " Order ALL the reference details at left...

Therapies and Procedures

1.	Transplants (Transplant) 01/27/2008 - "METHODS AND RESULTS: We found that an anti-angiogenic therapy (ABT-510 nonapeptide), devoid of direct immunomodulatory properties, dramatically reduced adventitial angiogenesis by 66% (P<0.0001) in the rat aortic interposition model of graft arteriosclerosis. " 11/01/1998 - "Although these grafts have become more technically feasible and have shown benefits, more follow-up data are needed to determine the long-term patency, freedom from arteriosclerosis, and efficacy of alternative conduits." 09/01/2006 - "The correlation between MMF and A20 provide an explanation for the mechanism by which MMF ameliorates transplant arteriosclerosis in an experimental animal model of chronic rejection." 03/01/2009 - "The aim of this study was to investigate the impact of CXCR5 on the development of transplant arteriosclerosis. " 08/27/2008 - "In this study, we report an important role for chemokine receptor CCR7 in the development of transplant arteriosclerosis. " Order ALL the reference details at left...
2.	Homologous Transplantation (Allograft) 03/01/2007 - "Fish oil ameliorates the allograft arteriosclerosis of intestine on rats." 12/01/2008 - "This study investigated regulation of the Notch pathway on cardiac allograft arteriosclerosis and further examined its implication in EC dysfunction. " 02/20/2002 - "BACKGROUND: Previous studies have suggested an independent role of ET-1 and PDGF in the development of cardiac allograft arteriosclerosis (i.e., chronic rejection). " 06/27/2001 - "BACKGROUND: Studies of cardiac allograft arteriosclerosis, i.e., chronic rejection, have largely focused on mononuclear inflammatory cell infiltrates in the vascular wall and periphery of the occluded vessels. " 06/01/1996 - "Chronic allograft arteriosclerosis: contributing factors and molecular mechanisms in the light of experimental studies." Order ALL the reference details at left...
3.	Transplantation (Transplant Recipients) 09/01/1996 - "Isolated coronary artery transplantation in pigs: a new model to study transplantation arteriosclerosis and humoral rejection." 02/01/1991 - "Accelerated arteriosclerosis in heart transplant recipients: an immunopathology study of 22 transplanted hearts." 11/01/1982 - "Arteriosclerosis in normal and von Willebrand pigs: long-term prospective study and aortic transplantation study." 08/01/2009 - "BACKGROUND: Transplantation of kidneys from donor with arteriosclerosis seen on pre-implantation biopsy has not been well studied. " 02/01/2009 - "The chronic rejection-associated arteriosclerosis was induced 28 days after the transplantation. " Order ALL the reference details at left...
4.	Kidney Transplantation 08/01/2009 - "Single versus dual renal transplantation from donors with significant arteriosclerosis on pre-implant biopsy." 01/01/2009 - "BACKGROUND: Color Doppler sonography indices, such as resistive index (RI) and pulsatility index (PI), can predict arteriosclerosis of internal renal vessels after kidney transplantation. " 03/01/2007 - "Severe arteriosclerosis is usually not a contraindication for kidney transplantation. " 01/01/2004 - "[Renal transplantation and arteriosclerosis in the transplanted organ]" 12/01/1994 - "Re: Reassessment of the value of post-vascularization biopsy performed at renal transplantation: the effects of arteriosclerosis." Order ALL the reference details at left...
5.	Endarterectomy (Thromboendarterectomy) 06/01/1990 - "Assessment of the severity of pulmonary arteriosclerosis and distal arterial patency indicated that most patients could have potentially benefited from surgical thromboendarterectomy. " 03/01/1991 - "From October 1985 to December 1988, 31 iliofemoral eversion endarterectomies were performed in 29 patients with arteriosclerosis. " 06/01/1989 - "The immediate postoperative development of the patients is promising and encourages us to proceed with this surgery (endarterectomy of the coronary artery) which is the only alternative method in the group of patients with diffuse distal arteriosclerosis of the coronary arteries." 01/01/1986 - "The procedure of choice for most patients was widening of the artery by venous patch grafting, in case of arteriosclerosis combined with endarterectomy. " 02/01/1957 - "The careful selection of patients with localized or segmental arteriosclerosis and well developed collateral circulation would seem to be the greatest factor in obtaining a maximum result by thromboendarterectomy." Order ALL the reference details at left...

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