Metastasis-Directed Radiotherapy for Oligoprogressive Castration-Resistant Prostate Cancer Recurrence Revealed by Choline PET/CT.

Abstract

We report a 49-year-old male with castration-resistant prostate cancer (CRPC) with oligometastasis diagnosed by 11C-choline positron emission tomography-computed tomography (PET/CT) and treated with target radiotherapy. In the diagnosis of CRPC (serum prostate-specific antigen [PSA] level of 6.53 ng/mL after maximum androgen blockade (MAB) therapy, high-dose brachytherapy, and external beam radiotherapy), 11C-choline PET/CT detected one tiny obturator lymph node metastasis which fluorodeoxyglucose PET/CT could not detect. He underwent intensity-modulated radiation therapy and MAB was restarted. The PSA value decreased and reached nadir (0.091 ng/mL) after 6 months. The time to PSA progression was 10 months. The choline PET/CT finding and the corresponding local treatment could play an important role in the management sequence of oligoprogressive CRPC.

• Authors: Kazuhiro Kitajima, Shingo Yamamoto, Masayuki Fujiwara, Hitomi Suzuki, Nahomi Yoshimura, Ryo Kunimoto, Hiroyuki Yokoyama, Hisashi Komoto, Yusuke Yamada, Seiji Nagasawa, Akihiro Kanematsu, Ryoong-Jin Oh, Koichiro Yamakado
• Journal: Case reports in oncology (Case Rep Oncol) 2021 Jan-Apr Vol. 14 Issue 1 Pg. 13-16 ISSN: 1662-6575 [Print] Switzerland
• PMID: 33613236 (Publication Type: Case Reports)
• Copyright: Copyright © 2021 by S. Karger AG, Basel.