Relationship of continuous glucose monitoring-related metrics with HbA1c and residual β-cell function in Japanese patients with type 1 diabetes.

Abstract

The targets for continuous glucose monitoring (CGM)-derived metrics were recently set; however, studies on CGM data over a long period with stable glycemic control are limited. We analyzed 194,279 CGM values obtained from 19 adult Japanese patients with type 1 diabetes. CGM data obtained during stable glycemic control over four months were analyzed. CGM-related metrics of different durations "within 120, 90, 60, 30, and 7 days" were calculated from baseline. Time in range (TIR; glucose 70-180 mg/dL), time above range (TAR; glucose ≥ 181 mg/dL), and average glucose levels, but not time below range (TBR; glucose ≤ 69 mg/dL), strongly correlated with glycated hemoglobin (HbA1c) values (P < 0.0001). TBR correlated with glucose coefficient of variation (CV) (P < 0.01). Fasting serum C-peptide levels negatively correlated with glucose CV (P < 0.01). HbA1c of approximately 7% corresponded to TIR of 74% and TAR of 20%. The shorter the CGM period, the weaker was the relationship between HbA1c and CGM-related metrics. TIR, TAR, and average glucose levels accurately reflected HbA1c values in Japanese patients with type 1 diabetes with stable glycemic control. Glucose CV and TBR complemented the limitation of HbA1c to detect glucose variability and hypoglycemia. Stable glycemic control with minimal hypoglycemia depended on residual β-cell function.

• Authors: Naru Babaya, Shinsuke Noso, Yoshihisa Hiromine, Yasunori Taketomo, Fumimaru Niwano, Sawa Yoshida, Sara Yasutake, Yumiko Kawabata, Hiroshi Ikegami
• Journal: Scientific reports (Sci Rep) Vol. 11 Issue 1 Pg. 4006 (02 17 2021) ISSN: 2045-2322 [Electronic] England
• PMID: 33597626 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Hypoglycemic Agents
• Insulin
• hemoglobin A1c protein, human
• Glucose

Topics

• Adult
• Aged
• Blood Glucose (analysis, chemistry)
• Blood Glucose Self-Monitoring (methods)
• Diabetes Mellitus, Type 1 (epidemiology, metabolism)
• Female
• Glucose (metabolism)
• Glycated Hemoglobin (analysis, metabolism)
• Humans
• Hypoglycemia (metabolism, physiopathology)
• Hypoglycemic Agents
• Insulin (metabolism)
• Insulin-Secreting Cells (metabolism, physiology)
• Japan (epidemiology)
• Male
• Middle Aged