Abstract | BACKGROUND: METHODS: Among 299 epithelial ovarian cancer cases and 334 matched controls, six inflammatory biomarkers were measured in plasma collected 1-24 years before diagnosis or index date using two custom multiplex Luminex panels. ORs and 95% confidence intervals (CI) were estimated for the association between each biomarker and risk using multivariable conditional logistic regression with adjustment for relevant confounders. We additionally assessed heterogeneity in the risk associations by histotype [high-grade serous carcinoma (HGSC) vs. non-HGSC], body mass index, smoking status, menopausal status, and aspirin use. RESULTS: Women with the highest versus lowest quartile (Q) levels of CXCL13 had a 72% increased ovarian cancer risk (OR = 1.72; 95% CI = 1.04-2.83; P trend = 0.007). The positive association with CXCL13 was stronger in magnitude for non-HGSC, overweight or obese women, and postmenopausal women, although only menopausal status demonstrated statistically significant heterogeneity (P interaction = 0.04). The remaining biomarkers were not associated with risk. CONCLUSIONS: IMPACT:
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Authors | Lauren C Peres, Mary K Townsend, Brenda M Birmann, Jose R Conejo-Garcia, Yongjoo Kim, Laura D Kubzansky, Larry I Magpantay, Otoniel Martinez-Maza, Shelley S Tworoger |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 30
Issue 4
Pg. 710-718
(04 2021)
ISSN: 1538-7755 [Electronic] United States |
PMID | 33563649
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | ©2021 American Association for Cancer Research. |
Chemical References |
- Biomarkers, Tumor
- Chemokine CXCL13
- Chemokines
- Cytokines
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Topics |
- Adult
- Biomarkers, Tumor
(blood)
- Carcinoma, Ovarian Epithelial
(blood)
- Case-Control Studies
- Chemokine CXCL13
(blood)
- Chemokines
(blood)
- Cytokines
(blood)
- Female
- Humans
- Inflammation
(blood)
- Middle Aged
- Nurses
- Ovarian Neoplasms
(blood)
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