The Landscape of Interactions between Hypoxia-Inducible Factors and Reactive Oxygen Species in the Gastrointestinal Tract.

Abstract

The gastrointestinal tract (GT) is the major organ involved in digestion, absorption, and immunity, which is prone to oxidative destruction by high levels of reactive oxygen species (ROS) from luminal oxidants, such as food, drugs, and pathogens. Excessive ROS will lead to oxidative stresses and disrupt essential biomolecules, which also act as cellular signaling molecules in response to growth factors, hormones, and oxygen tension changes. Hypoxia-inducible factors (HIFs) are critical regulators mediating responses to cellular oxygen tension changes, which are also involved in energy metabolism, immunity, renewal, and microbial homeostasis in the GT. This review discusses interactions between HIF (mainly HIF-1α) and ROS and relevant diseases in the GT combined with our lab's work. It might help to develop new therapies for gastrointestinal diseases associated with ROS and HIF-1α.

• Authors: Yirui Shao, Kexing Wang, Xia Xiong, Hongnan Liu, Jian Zhou, Lijun Zou, Ming Qi, Gang Liu, Ruilin Huang, Zhiliang Tan, Yulong Yin
• Journal: Oxidative medicine and cellular longevity (Oxid Med Cell Longev) Vol. 2021 Pg. 8893663 ( 2021) ISSN: 1942-0994 [Electronic] United States
• PMID: 33542787 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 Yirui Shao et al.

Chemical References

• Hypoxia-Inducible Factor 1, alpha Subunit
• Reactive Oxygen Species

Topics

• Animals
• Cell Hypoxia (physiology)
• Gastrointestinal Diseases (genetics, metabolism, pathology)
• Gastrointestinal Tract (drug effects, metabolism, pathology)
• Humans
• Hypoxia-Inducible Factor 1, alpha Subunit (physiology)
• Oxidative Stress (drug effects, physiology)
• Reactive Oxygen Species (metabolism, pharmacology)
• Signal Transduction (drug effects, physiology)