Abstract | BACKGROUND: METHODS: Plasma samples were obtained from 245 patients with advanced NSCLC and 30 healthy donors. Total RNA was extracted from the plasma samples, and TS and DHFR mRNA levels were determined via real-time PCR. TS and DHFR mRNA levels between cancer patients and healthy controls were compared. The association between plasma TS and DHFR mRNA levels and tumour response to pemetrexed/ cisplatin chemotherapy was analysed. RESULTS: The plasma TS and DHFR mRNA levels decreased in patients with advanced NSCLC compared with healthy controls. Moreover, plasma TS and DHFR mRNA levels negatively correlated with tumour response to pemetrexed/ cisplatin chemotherapy in patients with advanced NSCLC. Overall survival time was prolonged in patients with low TS mRNA expression compared with those with high TS mRNA expression, although the difference was not statistically significant. CONCLUSIONS:
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Authors | Tao Li, Jin-Bo Huang, Jun-Guo Lu, Rong Li, Yan Wang, Xiang-Rong Shi, Min-Xin Shi, Xiao-Dong Zhang |
Journal | Journal of thoracic disease
(J Thorac Dis)
Vol. 12
Issue 12
Pg. 7313-7319
(Dec 2020)
ISSN: 2072-1439 [Print] China |
PMID | 33447420
(Publication Type: Journal Article)
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Copyright | 2020 Journal of Thoracic Disease. All rights reserved. |