HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)

An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
Also Known As:
Dihydrofolate Reductase; Acid Reductase, Folic; Dehydrogenase, Dihydrofolate; Dehydrogenase, Tetrahydrofolate; Reductase, Dihydrofolate; Reductase, Folic Acid; Dihydrofolate Dehydrogenase; Folic Acid Reductase; 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase
Networked: 748 relevant articles (20 outcomes, 64 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Yuthavong, Yongyuth: 10 articles (01/2022 - 01/2002)
2. Queener, Sherry F: 9 articles (10/2011 - 01/2003)
3. Kamchonwongpaisan, Sumalee: 8 articles (01/2022 - 06/2006)
4. Rosowsky, Andre: 7 articles (03/2009 - 01/2002)
5. Gangjee, Aleem: 6 articles (11/2020 - 11/2003)
6. Chitnumsub, Penchit: 6 articles (12/2018 - 03/2003)
7. Bertino, Joseph R: 6 articles (02/2013 - 06/2003)
8. Banerjee, Debabrata: 5 articles (02/2013 - 06/2003)
9. Taweechai, Supannee: 4 articles (01/2022 - 11/2006)
10. Bharatam, Prasad V: 4 articles (04/2021 - 01/2008)

Related Diseases

1. Malaria
2. Neoplasms (Cancer)
3. Birth Weight (Birth Weights)
4. Leukemia
5. Falciparum Malaria (Plasmodium falciparum Malaria)

Related Drugs and Biologics

1. Dihydropteroate Synthase (Dihydropteroate Synthetase)
2. pyrimethamine drug combination fanasil (Fansidar)
3. Methotrexate (Mexate)
4. Enzymes
5. Folic Acid Antagonists
6. Thymidylate Synthase
7. Fluorouracil (Carac)
8. Thymidine Phosphorylase
9. Antimalarials (Antimalarial Agents)
10. Complementary DNA (cDNA)

Related Therapies and Procedures

1. Therapeutics
2. Adjuvant Chemotherapy
3. Chemoprevention
4. Drug Therapy (Chemotherapy)
5. Aftercare (After-Treatment)