Chest CT Diagnosis and Clinical Management of Drug-related Pneumonitis in Patients Receiving Molecular Targeting Agents and Immune Checkpoint Inhibitors: A Position Paper from the Fleischner Society.

Abstract

Use of molecular targeting agents and immune checkpoint inhibitors (ICIs) has increased the frequency and broadened the spectrum of lung toxicity, particularly in patients with cancer. The diagnosis of drug-related pneumonitis (DRP) is usually achieved by excluding other potential known causes. Awareness of the incidence and risk factors for DRP is becoming increasingly important. The severity of symptoms associated with DRP may range from mild or none to life-threatening with rapid progression to death. Imaging features of DRP should be assessed in consideration of the distribution of lung parenchymal abnormalities (radiologic pattern approach). The CT patterns reflect acute (diffuse alveolar damage) interstitial pneumonia and transient (simple pulmonary eosinophilia) lung abnormality, subacute interstitial disease (organizing pneumonia and hypersensitivity pneumonitis), and chronic interstitial disease (nonspecific interstitial pneumonia). A single drug can be associated with multiple radiologic patterns. Treatment of a patient suspected of having DRP generally consists of drug discontinuation, immunosuppressive therapy, or both, along with supportive measures eventually including supplemental oxygen and intensive care. In this position paper, the authors provide diagnostic criteria and management recommendations for DRP that should be of interest to radiologists, clinicians, clinical trialists, and trial sponsors, among others. This article is a simultaneous joint publication in Radiology and CHEST. The articles are identical except for stylistic changes in keeping with each journal's style. Either version may be used in citing this article. Published under a CC BY 4.0 license. Online supplemental material is available for this article.

• Authors: Takeshi Johkoh, Kyung Soo Lee, Mizuki Nishino, William D Travis, Jay H Ryu, Ho Yun Lee, Christopher J Ryerson, Tomás Franquet, Alexander A Bankier, Kevin K Brown, Jin Mo Goo, Hans-Ulrich Kauczor, David A Lynch, Andrew G Nicholson, Luca Richeldi, Cornelia M Schaefer-Prokop, Johny Verschakelen, Suhail Raoof, Geoffrey D Rubin, Charles Powell, Yoshikazu Inoue, Hiroto Hatabu
• Journal: Radiology (Radiology) Vol. 298 Issue 3 Pg. 550-566 (03 2021) ISSN: 1527-1315 [Electronic] United States
• PMID: 33434111 (Publication Type: Journal Article)