Plasma Inflammatory Biomarkers Associated with Advanced Liver Fibrosis in HIV-HCV-Coinfected Individuals.
Abstract | BACKGROUND: OBJECTIVE: This study aimed to provide an extensive profile of the plasma microbial translocation and inflammation biomarkers associated with advanced liver fibrosis among HIV-HCV-coinfected patients. METHODS: RESULTS: Of the 343 HIV-HCV-coinfected patients, 188 (54.8%) had severe or advanced liver fibrosis (FIB-4 > 3.25). The patients with advanced liver fibrosis (FIB-4 > 3.25 vs. FIB-4 ≤ 3.25) had higher plasma levels of interleukin (IL)-1β, IL-6, IL-7, IL-9, IL-12, IL-15, IL-17, granulocyte macrophage colony stimulating factor ( GM-CSF), Interferon-γ (IFN-γ), tumor necrosis factor (TNF-α), IL-4, IL-10, IL-13, fibroblast growth factor 2 (FGF-basic), and Monocyte chemoattractant protein-1 (MCP-1). Multivariable logistic regression models showed that advanced liver fibrosis was associated with an increased plasma level of IL-1β, IL-6, IL-7, IL-12, IL-17, GM-CSF, IFN-γ, IL-4, IL-10, MCP-1, Eotaxin, and FGF-basic, with FGF-basic continuing to be positively and significantly associated with advanced liver fibrosis, after Bonferroni correction for multiple comparisons (adjusted odds ratio (aOR) = 1.92; 95%CI: 1.32-2.81; p = 0.001). Plasma sCD14 was also significantly associated with advanced liver fibrosis (aOR = 1.13; 95%CI: 1.01-1.30; p = 0.049). CONCLUSIONS:
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Authors | Xiaochen Chen, Xing Liu, Song Duan, Renhai Tang, Sujuan Zhou, Runhua Ye, Yuecheng Yang, Jibao Wang, Shitang Yao, Na He |
Journal | International journal of environmental research and public health
(Int J Environ Res Public Health)
Vol. 17
Issue 24
(12 17 2020)
ISSN: 1660-4601 [Electronic] Switzerland |
PMID | 33348839
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Pharmaceutical Preparations
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Topics |
- Biomarkers
(blood)
- China
- Coinfection
(blood, diagnosis)
- Cross-Sectional Studies
- Female
- HIV Infections
(complications)
- Hepatitis C
(blood, complications, diagnosis)
- Humans
- Liver Cirrhosis
(blood, complications, diagnosis)
- Male
- Pharmaceutical Preparations
- Plasma
(chemistry)
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