Medical Management of Inoperable Malignant Bowel Obstruction.

Abstract

OBJECTIVE:

To review medical management of inoperable malignant bowel obstruction.

DATA SOURCES:

A literature review using PubMed and MEDLINE databases searching malignant bowel obstruction, etiology, types, pathophysiology, medical, antisecretory, anti-inflammatory, antiemetic drugs, analgesics, promotion of emptying, prevention of infection, anticholinergics, somatostatin analogs, gastric antisecretory drugs, prokinetic agents, glucocorticoid, opioid analgesics, antibiotics, enema, and adverse effects.

STUDY SELECTION AND DATA EXTRACTION:

Randomized or observational studies, cohorts, case reports, or reviews written in English between 1983 and November 2020 were evaluated.

DATA SYNTHESIS:

Malignant bowel obstruction (MBO) commonly occurs in patients with advanced or recurrent malignancies and severely affects the quality of life and survival of patients. Its management remains complex and variable. Medical management is the cornerstone of MBO treatment, with the goal of reducing distressing symptoms and optimizing quality of life. Until now, there has been neither a standard clinical approach nor registered medications to treat patients with inoperable MBO.

RELEVANCE TO PATIENT CARE AND CLINICAL PRACTICE:

This review provides information on the etiology, type and pathophysiology, and medical treatment of MBO and related adverse reactions of the drugs commonly used, which can greatly assist clinicians in making clinical decisions when treating MBO.

CONCLUSIONS:

Published research shows that medical management of MBO mainly consists of antisecretory, anti-inflammatory strategies, controlling vomiting and pain, promoting emptying, preventing infection, and combination therapy. Being knowledgeable about the most current treatment options, the related adverse effects, and the evidence supporting different practices is critical for clinicians to provide individualized medical therapy for MBO patients.

• Authors: Xiaoyan Huang, Jing Xue, Min Gao, Qiyuan Qin, Tenghui Ma, Xiaoyan Li, Hui Wang
• Journal: The Annals of pharmacotherapy (Ann Pharmacother) Vol. 55 Issue 9 Pg. 1134-1145 (09 2021) ISSN: 1542-6270 [Electronic] United States
• PMID: 33345552 (Publication Type: Journal Article, Review)

Chemical References

• Antiemetics
• Gastrointestinal Agents

Topics

• Antiemetics
• Gastrointestinal Agents (adverse effects)
• Humans
• Intestinal Obstruction (drug therapy)
• Neoplasms (complications, drug therapy)
• Quality of Life