Solid
tumors inevitably develop radioresistance due to low
oxygen partial pressure in the tumor microenvironment. Despite numerous attempts, there are still few effective ways to avoid the
hypoxia-induced poor radiotherapeutic effect. To overcome this problem,
platinum (Pt) nanodots were fabricated into a mesoporous
bismuth (Bi)-based nanomaterial to construct a biodegradable nanocomposite BiPt-
folic acid-modified amphiphilic
polyethylene glycol (PFA). BiPt-PFA could act as a radiosensitizer to enhance the absorption of X-rays at the
tumor site and simultaneously trigger response behaviors related to the tumor microenvironment due to the enrichment of materials in the
tumor area. During this process, the Bi-based component consumed
glutathione via coordination, thus altering the oxidative stress balance, while Pt nanoparticles catalyzed the decomposition of
hydrogen peroxide to generate
oxygen, thereby relieving tumor hypoxia. Both Pt and Bi thus co-modulated the tumor microenvironment to improve the radiotherapeutic effect. In addition, Pt dots in BiPt-PFA had strong near-infrared absorption ability and created an intensive photothermal
therapeutic effect. Modulation of the tumor microenvironment could thus improve the
therapeutic effect in hypoxic
tumors by a combination of
photothermal therapy and enhanced
radiotherapy. BiPt-PFA, as a biodegradable nanocomposite, may thus modulate the tumor microenvironment to enhance the hypoxic
tumor therapeutic effect by thermoradiotherapy.