[Vacuolar myelopathy after allogeneic bone marrow transplantation in a patient with acute lymphoblastic leukemia].

Abstract

Vacuolar myelopathy (VM) is known to be a neurological complication in patients with acquired immunodeficiency syndrome (AIDS). In autopsy-based studies, VM was reported in approximately 20-50% of patients with AIDS. It manifests in various says, mainly presenting as a painless spastic paraparesis with a sensory ataxia. We present a rare case of VM after bone marrow transplantation (BMT) in a patient without AIDS. A 50-year-old man developed weakness in the lower legs, leg muscle atrophy, and difficulty in walking 86 days after BMT. The patient died from septic shock on day 309. The autopsy revealed intralamellar vacuolation in the spinal white matter, which was compatible with VM.

• Authors: Takuma Kumagai, Noriko Doki, Takeshi Kobayashi, Rin Yamada, Tsunekazu Hishima, Hiroto Adachi, Ryosuke Konuma, Masahiro Fujita, Atsushi Wada, Yuya Kishida, Tatsuya Konishi, Akihito Nagata, Yuta Yamada, Satoshi Kaito, Kota Yoshifuji, Junichi Mukae, Megumi Akiyama, Kyoko Inamoto, Takashi Toya, Aiko Igarashi, Yuho Najima, Kazuhiko Kakihana, Hisashi Sakamaki, Kazuteru Ohashi
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 61 Issue 11 Pg. 1625-1627 ( 2020) ISSN: 0485-1439 [Print] Japan
• PMID: 33298658 (Publication Type: Case Reports, Journal Article)

Topics

• Bone Marrow Transplantation (adverse effects)
• Graft vs Host Disease
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Humans
• Male
• Middle Aged
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (therapy)
• Spinal Cord Diseases (etiology)