Transfusion in the mechanically ventilated patient.

Abstract

Red blood cell transfusions are a frequent intervention in critically ill patients, including in those who are receiving mechanical ventilation. Both these interventions can impact negatively on lung function with risks of transfusion-related acute lung injury (TRALI) and other forms of acute respiratory distress syndrome (ARDS). The interactions between transfusion, mechanical ventilation, TRALI and ARDS are complex and other patient-related (e.g., presence of sepsis or shock, disease severity, and hypervolemia) or blood product-related (e.g., presence of antibodies or biologically active mediators) factors also play a role. We propose several strategies targeted at these factors that may help limit the risks of associated lung injury in critically ill patients being considered for transfusion.

• Authors: Nicole P Juffermans, Cécile Aubron, Jacques Duranteau, Alexander P J Vlaar, Daryl J Kor, Jennifer A Muszynski, Philip C Spinella, Jean-Louis Vincent
• Journal: Intensive care medicine (Intensive Care Med) Vol. 46 Issue 12 Pg. 2450-2457 (12 2020) ISSN: 1432-1238 [Electronic] United States
• PMID: 33180167 (Publication Type: Journal Article, Review)

Topics

• Blood Transfusion
• Erythrocyte Transfusion (adverse effects)
• Humans
• Respiration, Artificial (adverse effects)
• Respiratory Distress Syndrome (etiology, therapy)
• Transfusion Reaction