Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis.

Abstract

Betel quid (BQ) chewing increased the risk of oral cancer and oral submucous fibrosis (OSMF), an oral premalignant disorder (OPMD) with malignant transformation potential. BQ components such as areca nut (AN), trauma by coarse AN fiber, catechin, copper, alkaloids, stimulated reactive oxygen species (ROS), inflammation and cytotoxicity are suggested to be the contributing factors. They may induce tissue inflammation, proliferation of fibroblasts and collagen deposition, myofibroblast differentiation and contraction, collagen cross-links and inhibit collagen phagocytosis, finally leading to the development of OSMF and oral cancer. These events are mediated by BQ components-induced changes of extracellular matrix (ECM) turnover via regulation of TGF-β1, plasminogen activator inhibitor-1 (PAI-1), cystatin, lysyl oxidase (LOX) and tissue inhibitors of metalloproteinases (TIMPs) and metalloproteinases (MMPs). Genetic susceptibility is also involved in these disease processes. Further understanding the molecular mechanisms of BQ-induced OSMF and oral cancer can be helpful for future disease prevention and treatment.

• Authors: Ru-Hsiu Cheng, Yi-Ping Wang, Julia Yu-Fong Chang, Yu-Hwa Pan, Mei-Chi Chang, Jiiang-Huei Jeng
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 21 Issue 21 (Oct 30 2020) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 33143101 (Publication Type: Journal Article, Review)

Chemical References

• Extracellular Matrix Proteins

Topics

• Areca (adverse effects)
• Extracellular Matrix (metabolism)
• Extracellular Matrix Proteins (metabolism)
• Genetic Predisposition to Disease
• Humans
• Oral Submucous Fibrosis (etiology, metabolism, pathology)