Genetic Predisposition to Disease (Genetic Predisposition)

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3085 relevant articles (24 outcomes, 409 trials/studies) found for this Disease

Description: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.

Also Known As:

Genetic Predisposition; Genetic Susceptibility; Genetic Predispositions; Predisposition, Genetic; Susceptibility, Genetic; Genetic Susceptibilities; Predispositions, Genetic; Susceptibilities, Genetic

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2442

Disease Attributes

Disease Susceptibility: 1845

Genetic Predisposition to Disease: 3085

Genetic Anticipation: 18

Genetic Phenomena

Genotype

Genetic Predisposition to Disease: 3085

Related Diseases

1.	Neoplasms (Cancer)
2.	Genetic Predisposition to Disease (Genetic Predisposition)
3.	Lung Neoplasms (Lung Cancer)
4.	Hypertension (High Blood Pressure)
5.	Infection

Experts

1.	Ollier, W E R: 6 articles (08/2007 - 02/2002)
2.	Taioli, Emanuela: 5 articles (01/2008 - 02/2005)
3.	Bayat, A: 5 articles (08/2007 - 02/2002)
4.	Thelma, B K: 4 articles (10/2007 - 01/2005)
5.	Bayat, Ardeshir: 4 articles (02/2007 - 02/2003)
6.	Ferguson, M W J: 4 articles (02/2004 - 02/2002)
7.	Wu, Xifeng: 3 articles (09/2008 - 12/2004)
8.	Bonassi, Stefano: 3 articles (07/2008 - 12/2005)
9.	Puntoni, Riccardo: 3 articles (07/2008 - 12/2005)
10.	Neri, Monica: 3 articles (07/2008 - 12/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Genetic Predisposition to Disease:

1.	Biological Markers (Surrogate Marker)IBA 12/01/1995 - "Recent advances in genetic predisposition, biomarkers, photodiagnostic imaging, and differentiation therapy may soon offer improved outcomes. " 10/01/2008 - "Further human studies are needed which will consider the exposition window, the association of several xenoestrogens, the molecular mechanisms involved and the possible individual genetic susceptibility in order to identify pertinent biomarkers and to define acceptable environmental concentration levels for agricultural or industrial chemical new products to be used." 03/01/2001 - "In these studies, high-risk individuals are identified by their genetic predisposition to diabetes, and/or by the presence of immune markers indicating activation of the autoimmune process directed against islet cells. " 09/05/1999 - "Carcinogen biomarkers have proven to be important tools in research studies of exposure and genetic susceptibility. " 06/01/1998 - "The use of biomarkers of genetic susceptibility in the study of these diseases will be discussed. " Order ALL the reference details at left...
2.	Insulin (Novolin)FDA Link 04/01/1999 - "Our data suggest that insulin secretion, when expressed as an index normalized for insulin sensitivity, is more familial than either insulin sensitivity or first phase insulin secretion alone and may be a very useful trait for identifying genetic predisposition to type 2 diabetes." 12/08/1989 - "Recent studies indicate that the subset of insulin-dependent diabetic patients who develop nephropathy may have a genetic susceptibility to renal injury resulting from the abnormal physiologic milieu associated with diabetes. " 10/01/2009 - "Genetic susceptibility to type 1 diabetes correlates inversely with thymic insulin expression and, in mice, lowered levels of this expression result in T cell responses against insulin. " 05/01/2009 - "We conclude that, in IGT, an increased genetic predisposition for T2DM increases the contribution of impaired insulin secretion to its pathophysiology. " 01/01/2008 - "Type 1 diabetes results from a T cell-mediated autoimmune destruction of the insulin-producing pancreatic beta cells in subjects with a genetic predisposition to this disease. " Order ALL the reference details at left...
3.	AntigensIBA 01/01/1996 - "Analysis of relations between the above antigens, the disease risk, clinical and laboratory parameters, readings of ultrasound histogram and the efficacy of treatment helped discover not only provoking and protecting genes, but also some pathogenetic mechanisms involved in genetic predisposition. " 04/01/2008 - "OBJECTIVE: To study the human leukocyte antigen (HLA) genes to genetic predisposition in diffuse panbronchiolitis (DPB). " 01/01/2008 - "AREAS OF AGREEMENT: Early genetic studies identified the most important region for genetic susceptibility to T1D-the human leukocyte antigen genes on chromosome 6; later shown to contribute approximately half of the genetic determination of T1D. " 05/01/2007 - "Several studies have suggested that genetic susceptibility to RHD may be linked to human leukocyte antigen (HLA) class II alleles. " 11/15/2006 - "A number of genetic susceptibility factors have been proposed, but with exception of the human leukocyte antigen CHLA, class II, have not shown consistent results among studies. " Order ALL the reference details at left...
4.	gamma-Aminobutyric Acid (GABA)IBA 04/01/1996 - "The pivotal function of ionotropic gamma-aminobutyric acid type A receptors (GABRs) in inhibitory neurotransmission in the mammalian central nervous system suggests that they may be involved in epileptogenesis and genetic predisposition to IGEs. " 03/01/1986 - "These data and previous studies support a role for increased excitant amino acid action and decreased efficacy of GABA in the inferior colliculus as important mechanisms involved in genetic susceptibility to audiogenic seizures." 02/20/2003 - "In the present study the molecular composition of other GABA(A) subunits (beta2, alpha1 and gamma2) were analyzed in order to further investigate the involvement of the GABA(A) receptors in the genetic predisposition to voluntary alcohol intake. " 03/05/2001 - "Our data show for the first time that a mutated GABA(A) alpha(6) receptor subunit segregates in a rat line which voluntarily avoids alcohol consumption, and further support a possible involvement of the GABA(A) receptor containing a mutated alpha(6) subunit in the genetic predisposition to alcohol preference." 08/09/2002 - "In the present study, we used in vivo microdialysis to measure the levels of extracellular GABA (gamma-aminobutyric acid) and glutamate during seizure development in rats with a genetic predisposition for (Fast), or against (Slow), amygdala kindling. " Order ALL the reference details at left...
5.	Carbon MonoxideIBA 12/01/1999 - "This study used a family study method and examined the transmission of PNE in relatives of PNE and control probands with and without ADHD, to determine if these disorders co-occur due to common genetic susceptibilities or other, i.e. " 11/01/2009 - "Results argued against a causal nonshared environmental influence of peer affiliation on the development of externalizing behaviors and in favor of nonshared environmental "selection." In particular, the twin with more externalizing behaviors at age 14 reported increased deviant peer affiliation relative to his or her co-twin 3 years later, regardless of his or her genetic predispositions toward externalizing behavior. " 03/01/2009 - "The reduction found in the non-demented MZ co-twins may be an indicator of genetic susceptibility to AD." 01/01/2009 - "One of these tested CO feedback alone and CO + genetic susceptibility as two different intervention; none of the three possible comparisons detected significant effects. " 09/01/2008 - "The basis of this effect modification is uncertain, but might include differences among SES strata in co-exposures to other neurotoxicants, genetic susceptibilities, environmental enrichment, and stress. " Order ALL the reference details at left...
6.	SodiumIBA 03/01/2005 - "Delayed clearance of fetal lung liquid and sodium transport--genetic predisposition not evident yet." 07/01/2008 - "Sweating during exercise, especially during exercise in the heat, leads to sodium and water losses, and the quantity of these losses depends upon the intensity and duration of the activity, genetic predisposition and conditioning of the individual, and environmental factors. " 06/01/1992 - "The researchers have offered 2 opposing explanations: the hypothesis of the genetic susceptibility to sodium and the hypothesis of a weak association in general population. " 03/01/1982 - " It can be postulated that sodium retention, and genetic predisposition to react to elevation of the whole-body sodium content by an increase in blood pressure, are determining for the pathogenesis of this condition. " 12/01/2004 - "The goal of this study was to evaluate the hypothesis that, where there is a genetic predisposition to Ang II-dependent hypertrophy, there is also an increased susceptibility to sodium-induced hypertrophy mediated by AT1-receptor expression. " Order ALL the reference details at left...
7.	CalciumIBA 10/01/2001 - "A novel explanation for this phenomenon is that a genetic predisposition for low calcium absorption efficiency exists that can be alleviated by a simple dietary change--improved calcium intake." 06/01/2003 - "The correlation of the other risk factors with calcium score is unclear and whether this is due to genetic predisposition requires further investigation." 01/09/1999 - "The CASR A986S polymorphism is a likely candidate locus for genetic predisposition to various bone and mineral disorders in which extracellular calcium concentrations have a prominent part." 09/01/1996 - "However, the concurrence of a genetic predisposition seem to be crucial for calcium stone formation. " 07/01/1991 - "From the present studies, the genomic source of the adenomatous colonic lines appear to modify the effect of increased calcium on mucosal growth as demonstrated by differences in growth response in lines with and without the biomarker associated with genetic predisposition for some colon cancers, increased in vitro tetraploidy. " Order ALL the reference details at left...
8.	ReninIBA 07/01/2008 - "The results are evidence of similarities and some definite differences in genetic nature of the different forms of low-renin AH and, to say more widely, argue that the investigation of genetic predisposition for clinically heterogeneous forms of polygene diseases by comparison of groups of patients, separated in accordance with peculiarities of disease course, holds much promise for their hereditary background understanding." 01/01/1998 - "Additional risk factors/ markers for development of nephropathy are male sex, genetic predisposition, ethnic conditions, early onset of diabetes, poor metabolic control, hyperfiltration, elevated prorenin and smoking. " 12/01/1999 - "The renin (REN) gene is a good candidate that could underlie an individual's genetic susceptibility to human essential hypertension (EHT). " 01/01/1994 - "Because renin is thought to be a candidate gene for essential hypertension, a prospective study was conducted to compare the frequency of renin gene HindIII restriction fragment length polymorphism (RFLP) in normotensive and hypertensive subjects without (HTG-) and with a genetic predisposition to essential hypertension (HTG+). " 01/01/1994 - "Frequency of renin gene restriction fragment length polymorphism in hypertensives with a genetic predisposition to hypertension." Order ALL the reference details at left...
9.	MutagensIBA 04/01/2001 - "The sensitivity and specificity of the CA assay are improved with the use of the fluorescence in situ hybridization (FISH) procedure, which employs a variety of chromosome-specific and chromosome region-specific fluorescence probes to elucidate CA. Factors that influence the expression of CA in a population study include inadequate study design, genetic variations in metabolism of chemicals (genetic susceptibility), and lifestyle differences in response to exposure to environmental mutagens (acquired susceptibility). " 09/20/2000 - "Although many factors can contribute to variability in human biomonitoring studies, genetic susceptibility (the influence of polymorphic metabolising genes on response to environmental mutagens) should be considered whenever appropriate. " 04/01/1986 - "This variability may be viewed as subtle inherent genetic predisposition of sensitivity to mutagens that could be evaluated only using sensitive measures (e.g., SCE and not micronuclei) following more than one mutagenic challenges. " 02/01/1983 - "These findings imply that lymphoblastoid lines may not always be the appropriate cell type for investigating genetic susceptibility to chemical mutagens." 01/01/1996 - "Screening for genetic predisposition to mutagens in cancer patients." Order ALL the reference details at left...
10.	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 08/01/2009 - "This information could be helpful for designing future public health strategies, as it can be used to predict the prevalence of several disorders associated with genetic predisposition due to methylenetetrahydrofolate reductase C677T alleles." 12/01/1998 - "A thermolabile form of the enzyme methylene tetrahydrofolate reductase (MTHFR) has been proposed as a major cause of a genetic predisposition to hyperhomocysteinaemia and a point mutation at nucleotide 677 of the MTHFR gene causing a thermolabile MTHFR has been described. " 04/01/1997 - "A common cause of hyperhomocystinemia is a genetic predisposition caused by a polymorphic substitution in the methylenetetrahydrofolate reductase (MTHFR) gene, which can be readily detected by molecular means. " 01/01/2006 - "Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis." 07/01/1997 - "Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR)." Order ALL the reference details at left...

Therapies and Procedures

1.	Chemoprevention 11/01/1995 - "Exposure-specific strategies are described; these are such things as health promotion and behavior modification, legislative approaches, treatment for addiction, changes in the food supply, chemoprevention, occupational and environmental regulation, immunization, identification of persons with enhanced genetic susceptibility, and improved surveillance systems. " 08/01/2008 - "Surveillance, chemoprevention, and prophylactic surgery are accepted options for managing individuals who have a genetic predisposition for cancer. " 07/01/2005 - "PURPOSE OF REVIEW: The current article reviews recent advances in genetic susceptibility and chemoprevention of lung cancer. " 01/21/2005 - "Chemoprevention is a particularly useful method in the management of patients at high risk for the development of specific cancers based on inborn genetic susceptibility, the presence of cancer-associated disease, or other known risk factors. " 02/01/2003 - "As information from the Human Genome Project becomes integrated into clinical practice, knowledge of genetic susceptibility for lung cancer will be used to identify persons at risk and to individualize treatments, such as prescribing chemoprevention. " Order ALL the reference details at left...
2.	Arthroplasty 02/01/2009 - "Genetic susceptibility to hip arthroplasty failure-association with the RANK/OPG pathway." 06/01/2006 - "Genetic susceptibility to hip arthroplasty failure--association with the RANK/OPG pathway." 02/01/2007 - "Genetic susceptibility to total hip arthroplasty failure--positive association with mannose-binding lectin." 08/01/2007 - "Genetic susceptibility to total hip arthroplasty failure: a preliminary study on the influence of matrix metalloproteinase 1, interleukin 6 polymorphisms and vitamin D receptor." 12/01/2006 - "In a matched, controlled study, we defined the major genetic predispositions that increase the risk of venous thromboembolism after total hip arthroplasty: deficiency of antithrombin III (< 75%) and protein C (< 70%), and prothrombin gene mutation. " Order ALL the reference details at left...
3.	Self Administration (Administration, Self) 12/01/2004 - "The objective of this study was to test the potential interaction between genetic predisposition to consume alcohol and alcohol pretreatment on subsequent self-administration. " 02/01/2001 - "In addition, studies have shown that some genes in mice seem to affect both alcohol self-administration and alcohol withdrawal severity: genetic predisposition to high levels of drinking covaries with genetic predisposition to low withdrawal severity, and vice versa. " 02/01/2009 - "Genetic predisposition to ethanol self-administration did not interact with development of behavioral sensitization in either adolescents or adults. " 01/01/1998 - "In addition, animal models of chronic ethanol self-administration have been developed in rodents, who do not have a genetic predisposition for high alcohol-seeking behavior, to explore environmental influences in ethanol drinking and the effects of physical dependence on alcohol self-administration. " 02/01/2009 - "Furthermore, genetic predisposition to high or low ethanol self-administration does not seem to be a factor that influences individual vulnerability to the neurobehavioral effects of repeated administration of nicotine." Order ALL the reference details at left...
4.	Drug Therapy (Chemotherapy) 12/01/2009 - "This association maybe explained by either greater chemotherapy exposure or an interaction between therapy and genetic predisposition." 02/01/2008 - "Among others, the disease itself, chemotherapy, irradiation and genetic susceptibility play a role. " 04/01/2007 - "The investigation of additional factors that may contribute to cognitive outcome, such as the effects of treatments other than chemotherapy and genetic susceptibility, is likely to further advance the field." 01/01/2007 - "A genetic predisposition may be essential for the occurrence of such a highly malignant primary brain tumour in leukaemia patients, irrespective of radiation and/or chemotherapy. " 08/01/2006 - "We hypothesized that polymorphisms in cytokine gene promoters may underlie genetic susceptibility to chemotherapy-induced toxicities in the Japanese. " Order ALL the reference details at left...
5.	Transplants (Transplant) 01/01/2009 - "CONCLUSION: The high incidence of KS in this large population studied, as compared to that reported in other transplant patient groups, suggests that genetic predisposition may play a pathogenetic role." 05/15/2005 - "Lower survival of offspring donor grafts may suggest genetic susceptibility because such donors were, in general, younger than in LURD grafts." 11/15/1998 - "Our results suggest that patient cytokine gene polymorphism genotypes may influence GVHD outcome by affecting cytokine activation during the pretransplant conditioning regimens, and these results are the first to suggest a genetic predisposition to this important transplant-related complication." 01/01/1996 - "More importantly, they are expected to play a central role in medicine, particularly the diagnosis and prognosis of genetic diseases including genetic predispositions, the assessment of treatments including transplants and decisions on reproductive choices. " 05/01/2006 - "Thus, the pre-transplant analysis of the patients' genetic predisposition may be considered as important factor allowing the classification of the transplant recipients as less or more susceptible for developing toxic lesions, severe and/or fatal acute GvHD or viral reactivation. " Order ALL the reference details at left...

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