Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS:
Overweight asthma patients had a higher annual exacerbation rate, lower pulmonary function even when treated frequently with high-dose inhaled corticosteroids, and a significantly lower percentage of eosinophils and lower eosinophil count compared to non- overweight asthma patients (p<0.01, p=0.03). Moreover, the percentage of eosinophils was significantly negatively correlated with BMI (ρ=-0.38, p<0.01) (Figure 1). On serum cytokine and chemokine analyses, the overweight asthma group included significantly more patients with a lower level of tissue growth factor α (TGF-α) (1.1 pg/mL) and higher levels of hsIL-6 (2.5 pg/mL), RANTES/CCL5 (298.5 pg/mL), and vascular endothelial growth factor A ( VEGF-A) (63.7 pg/mL), than the non- overweight asthma group (p=0.02, p<0.01, p=0.02, p=0.01, respectively). CONCLUSION:
|
Authors | Hiroki Tashiro, Koichiro Takahashi, Hironori Sadamatsu, Yuki Kurihara, Tetsuro Haraguchi, Ryo Tajiri, Ayako Takamori, Shinya Kimura, Naoko Sueoka-Aragane |
Journal | Journal of asthma and allergy
(J Asthma Allergy)
Vol. 13
Pg. 409-414
( 2020)
ISSN: 1178-6965 [Print] New Zealand |
PMID | 33061467
(Publication Type: Journal Article)
|
Copyright | © 2020 Tashiro et al. |