Evaluation of a novel biodegradable ureteral stent produced from polyurethane and magnesium alloys.

Abstract

Indwelling ureteral stents represent a very frequently used procedure in urological clinical practice that ensures the drainage of urine from the upper urinary tract. However, the stents could result in many stent-associated complications, such as encrustation and patient discomfort. We developed a new type of biodegradable ureteral stents produced from degradable polyurethane and magnesium alloys. In the present study, we investigated the biocompatibility and the property of degradation of the biodegradable ureteral stents. We evaluated the cytotoxicity of biodegradable ureteral stent by the MTT assay in vitro. The rabbit dorsal muscle embedding test was used to assess the biocompatibility of the degradable stents. Inflammation and fibrosis of muscle tissue were noted to evaluate compatibility at 1, 2, 4, 6 weeks after stents implanted in muscle. The degradation of the biodegradable ureteral stents was assessed by measuring the weight loss of the samples in AUS (artificial urine solution). For validating the degradation property of degradable stents in vivo, we inserted a degradable stent or a conventional biostable stent into Bama pigs. Furthermore, blood studies, liver function tests, renal function tests, urine studies, and computerized tomography (CT) were performed postoperatively. Our study confirms that the degradable polyurethane-based biodegradable ureteral stent has good biocompatibility. Our biodegradable ureteral stents were completely degraded within 4 weeks and provided a better ability of drainage than conventional stents. They hold promise for decreasing the need for a secondary procedure and stent related morbidity, such as infections.

• Authors: Lu Jin, Lei Yao, Feng Yuan, Guangcheng Dai, Boxin Xue
• Journal: Journal of biomedical materials research. Part B, Applied biomaterials (J Biomed Mater Res B Appl Biomater) Vol. 109 Issue 5 Pg. 665-672 (05 2021) ISSN: 1552-4981 [Electronic] United States
• PMID: 32929829 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 Wiley Periodicals LLC.

Chemical References

• Alloys
• Biocompatible Materials
• Polyurethanes
• Tetrazolium Salts
• Thiazoles
• thiazolyl blue
• Magnesium

Topics

• Alloys
• Animals
• Biocompatible Materials (chemistry)
• Cell Survival
• Female
• Magnesium (chemistry)
• Mice
• Microscopy, Electron, Scanning
• Muscle, Skeletal (physiology)
• Polyurethanes (chemistry)
• Pressure
• Rabbits
• Stents
• Swine
• Tetrazolium Salts (chemistry)
• Thiazoles (chemistry)
• Ureter (surgery)