Engineering bacterial outer membrane vesicles as transdermal nanoplatforms for photo-TRAIL-programmed therapy against melanoma.

Abstract	Melanoma is an aggressive cancer with rapid progression, relapse, and metastasis. Systemic therapies for melanoma exhibit limited anticancer potential and high toxicity. Here, we developed the outer membrane vesicles derived from transgenic Escherichia coli, modified with αvβ3 integrin peptide targeting ligand and indocyanine green (named as I-P-OMVs), to induce the transdermal photo-TRAIL-programmed treatment in skin melanoma.-OMVs, which are outer membrane vesicles derived from transgenic Escherichia coli, modified with αvβ3 integrin targeting ligand and indocyanine green (named as I-P-OMVs), to induce the transdermal photo-TRAIL-programmed treatment in skin melanoma. I-P-OMVs exhibited excellent stratum corneum penetration and specificity to melanoma. Upon near-infrared irritation, I-P-OMVs not only induced photothermal-photodynamic responses against primary melanoma spheroids but also activated TRAIL-induced apoptosis in disseminated tumor cells, resulting in a complete eradication of melanoma. I-P-OMVs are the first nanoplatforms to induce transdermal photo-TRAIL-programmed therapy in melanoma with enhanced antitumor performance and high safety, having great potential in cancer therapy.
Authors	Li-Hua Peng, Mao-Ze Wang, Yang Chu, Lei Zhang, Jie Niu, Hai-Tao Shao, Tie-Jun Yuan, Zhi-Hong Jiang, Jian-Qing Gao, Xing-Hai Ning
Journal	Science advances (Sci Adv) Vol. 6 Issue 27 Pg. eaba2735 (07 2020) ISSN: 2375-2548 [Electronic] United States
PMID	32923586 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Chemical References	Bacterial Outer Membrane Proteins Integrin beta3 Ligands Indocyanine Green
Topics	Bacterial Outer Membrane Bacterial Outer Membrane Proteins Escherichia coli (chemistry) Humans Indocyanine Green Integrin beta3 Ligands Melanoma (drug therapy)

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