A 58-year-old male patient with
diabetic foot ulcer was admitted to the Second Affiliated Hospital of Zhejiang University School of Medicine on December 11, 2018. The patient was treated with local
debridement, vacuum sealing drainage treatment, and dressing change and discharged after basic wound healing. On January 15, 2019, the patient was hospitalized again due to local
infection and
rupture of
wound surface. He underwent a surgical
debridement on the third day after second admission and was given
intravenous infusion of 0.4 g
teicoplanin twice daily. Histopathological examination after surgery showed keratinizing
squamous-cell carcinoma. An extended
squamous-cell carcinoma resection plus autologous split-thickness
skin grafting and vacuum sealing drainage treatment was carried out on the 10th day after second admission. The patient's whole body turned red after surgery with
rash, recurrent
fever over 39 ℃, leucopenia, and
thrombocytopenia. A multi-disciplinary consultation of physicians attributed these symptoms to
teicoplanin-induced
hypersensitivity syndrome. After withdrawal of
teicoplanin and administration of
hormone, the patient's temperature returned to normal, and the leucocyte count and platelet count recovered gradually. The patient was cured and discharged on the 49th day after second admission. The case presented reminds us of need to strictly follow the indications of
teicoplanin prior to medication, be resolute to the administration and withdrawal, and be alert to
adverse drug reactions when above-mentioned abnormalities occur, meanwhile,
infection and
rheumatic diseases are excluded.