Abstract | BACKGROUND:
Hyperglycemia, a derangement after subarachnoid hemorrhage (SAH), is known to be associated with unfavorable outcomes. Whether the connection between hyperglycemia and poor prognosis results from severe neuronal apoptosis is unknown, and we aim at investigating their relationship. MATERIAL AND METHODS: RESULTS: When subjected to SAH, hyperglycemic animals had worse neurobehavioral functions than normoglycemic ones. Hyperglycemia-exacerbated apoptosis was evident by greater increases in cleaved caspase-3 expression and TUNEL-positive cell density in the SAH with hyperglycemia group than those in the SAH only group, whereas there was no significant difference in cleaved caspase-9 expression and Bax/Bcl-2 ratio between the two groups. Furthermore, there was a remarkable decrease in the ratio of phosphorylated extracellular regulated kinase (ERK)/total ERK in the hyperglycemic rats after SAH. CONCLUSION:
Hyperglycemia aggravated neuronal apoptosis after SAH and was associated with impaired neurological outcomes. Activation of the extrinsic caspase cascade through the ERK signal pathway may contribute to hyperglycemia-mediated apoptosis.
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Authors | Yu-Hua Huang, Chia-Li Chung, Hung-Pei Tsai, Rong-Dar Tzou, Shu-Chuan Wu, Chee-Yin Chai, Tao-Chen Lee, Aij-Lie Kwan |
Journal | International journal of surgery (London, England)
(Int J Surg)
Vol. 83
Pg. 246-252
(Nov 2020)
ISSN: 1743-9159 [Electronic] United States |
PMID | 32739549
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Streptozocin
- Extracellular Signal-Regulated MAP Kinases
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Topics |
- Animals
- Apoptosis
- Brain
(pathology)
- Extracellular Signal-Regulated MAP Kinases
(metabolism)
- Hyperglycemia
(pathology)
- Male
- Neurons
(pathology)
- Rats
- Rats, Sprague-Dawley
- Streptozocin
- Subarachnoid Hemorrhage
(complications, pathology)
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