Abstract | BACKGROUND: METHODS: In a two-stage, double-blinded clinical trial, 296 participants were randomized to receive 8 weeks of sertraline or placebo in stage 1. Individuals who responded continued on another 8-week course of the same intervention in stage 2, while sertraline and placebo nonresponders crossed over to bupropion and sertraline, respectively. Data from 241 participants were analyzed. The stage 2 sample comprised 87 patients with major depressive disorder who switched medication and 38 healthy control subjects. A total of 116 participants with major depressive disorder treated with sertraline in stage 1 served as an independent replication sample. The probabilistic reward task and resting-state functional magnetic resonance imaging were administered at baseline. RESULTS: Greater pretreatment reward sensitivity and higher resting-state functional connectivity between bilateral nucleus accumbens and rostral anterior cingulate cortex were associated with positive response to bupropion but not sertraline. Null findings for sertraline were replicated in the stage 1 sample. CONCLUSIONS:
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Authors | Yuen-Siang Ang, Roselinde Kaiser, Thilo Deckersbach, Jorge Almeida, Mary L Phillips, Henry W Chase, Christian A Webb, Ramin Parsey, Maurizio Fava, Patrick McGrath, Myrna Weissman, Phil Adams, Patricia Deldin, Maria A Oquendo, Melvin G McInnis, Thomas Carmody, Gerard Bruder, Crystal M Cooper, Cherise R Chin Fatt, Madhukar H Trivedi, Diego A Pizzagalli |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 88
Issue 8
Pg. 657-667
(10 15 2020)
ISSN: 1873-2402 [Electronic] United States |
PMID | 32507389
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Serotonin Uptake Inhibitors
- Bupropion
- Sertraline
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Topics |
- Adult
- Bupropion
- Depressive Disorder, Major
(drug therapy)
- Humans
- Prospective Studies
- Reward
- Selective Serotonin Reuptake Inhibitors
- Sertraline
- Treatment Outcome
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