Abstract | PURPOSE: METHODS: The COPD model rats were treated with Feikang granules, dexamethasone, or normal saline. The pulmonary function; lung tissue histology; levels of inflammatory cytokines; mRNA levels of TNFα, IL-6, TLR4, and TLR2; and protein levels of TLR4, TLR2, p-IκB, IκB and P65 in lung tissues were evaluated. RESULTS: The present study confirmed that the pro-inflammatory cytokines, TNF-α, IL-1β, IL-6, and IL-17 levels were elevated and the pulmonary function and morphology are altered in COPD model rats. The TLR2 and TLR4 -mediated NF-kB signaling pathway plays a role in the mechanism of action. Feikang granules, a type of Chinese herbal medicine, significantly reduced LPS induced inflammatory cytokines release from lung tissue and alveolar macrophage in a dose-dependent manner. These medical herbs also prevented TLR2/4 and IκB downregulation and reversed the p-IκB and NF-κB p65 upregulation of the lung tissue in the COPD rats. Feikang granules were also found to protect against pulmonary dysfunction and pathological changes in the COPD rats. CONCLUSION: The Chinese herbal medicine formula Feikang granules prevent pulmonary inflammation and improve pulmonary function, suggesting that Feikang granules may be an effective treatment for chronic pulmonary diseases, such as COPD.
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Authors | Liuliu Yang, Minyong Wen, Xiaohong Liu, Kai Wang, Yong Wang |
Journal | BMC complementary medicine and therapies
(BMC Complement Med Ther)
Vol. 20
Issue 1
Pg. 170
(Jun 03 2020)
ISSN: 2662-7671 [Electronic] England |
PMID | 32493287
(Publication Type: Journal Article)
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Chemical References |
- Drugs, Chinese Herbal
- NF-kappa B
- Tlr2 protein, rat
- Tlr4 protein, rat
- Toll-Like Receptor 2
- Toll-Like Receptor 4
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Topics |
- Animals
- Disease Models, Animal
- Drugs, Chinese Herbal
(pharmacology)
- Male
- NF-kappa B
(metabolism)
- Pneumonia
(drug therapy)
- Pulmonary Disease, Chronic Obstructive
(drug therapy)
- Rats
- Rats, Sprague-Dawley
- Signal Transduction
- Toll-Like Receptor 2
(metabolism)
- Toll-Like Receptor 4
(metabolism)
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