Abstract | BACKGROUND: METHODS: A miRNome PCR array was used to analyse the plasma of psoriasis patients and healthy donors. We performed miRNA pathway enrichment and target gene network analyses on psoriasis plasma samples. RESULTS: We found several specific plasma miRNA signatures relevant to psoriasis. The miRNAs targeted pathways associated with psoriasis, such as the VEGF, MAPK, and WNT signaling pathways. Network analysis revealed pivotal deregulated plasma miRNAs and their relevant target genes and pathways regulating psoriasis pathogenesis. CONCLUSIONS: This study analysed the expression of plasma miRNAs and their target pathways, elucidating the pathogenesis of psoriasis; these results may be used to design novel therapeutic strategies and to identify diagnostic biomarkers for psoriasis.
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Authors | Shiju Xiao, Xin Liu, Xiaoxu Wang, Hongpeng Lv, Junbo Zhao, Xinwei Guo, Fuyang Xian, Yunrun Ji, Guangzhong Zhang |
Journal | Journal of immunology research
(J Immunol Res)
Vol. 2020
Pg. 1561278
( 2020)
ISSN: 2314-7156 [Electronic] Egypt |
PMID | 32411787
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Shiju Xiao et al. |
Chemical References |
- Biomarkers
- Circulating MicroRNA
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
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Topics |
- Adult
- Biomarkers
(blood, metabolism)
- Circulating MicroRNA
(blood, metabolism)
- Female
- Gene Expression Profiling
- Gene Regulatory Networks
(immunology)
- Humans
- MAP Kinase Signaling System
(genetics, immunology)
- Male
- Middle Aged
- Psoriasis
(blood, diagnosis, genetics, immunology)
- Vascular Endothelial Growth Factor A
(metabolism)
- Wnt Signaling Pathway
(genetics, immunology)
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