Abstract | BACKGROUND: DESIGN: RESULTS: We found increased concentrations of total Hcy (P < .01) and total CysGly (P < .05) in COPD patients when compared to controls. Total Hcy and CysGly were also significantly associated with abnormal lung function parameters and COPD severity. In COPD patients, total Hcy was significantly associated with the Kyn/Trp ratio (P = .0017) whereas total CysGly was significantly associated with both PSH (P = .0298) and the Kyn/Trp ratio (P = <.0001). CONCLUSION: Both total Hcy and CysGly concentrations were significantly associated with the presence and severity of COPD and with markers of oxidative stress (total CysGly) and inflammation (total Hcy and CysGly). This suggests that specific low molecular mass thiols might play a role in the inflammatory and oxidative stress pathways involved in both CVD and COPD.
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Authors | Angelo Zinellu, Elisabetta Zinellu, Elisabetta Sotgiu, Alessandro G Fois, Panagiotis Paliogiannis, Valentina Scano, Barbara Piras, Salvatore Sotgia, Arduino A Mangoni, Ciriaco Carru, Pietro Pirina |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Pg. e13267
(May 07 2020)
ISSN: 1365-2362 [Electronic] England |
PMID | 32378181
(Publication Type: Journal Article)
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Copyright | © 2020 Stichting European Society for Clinical Investigation Journal Foundation. |