Abstract | PURPOSE: METHODS: Literature searches were performed to the function of COX-2-PGE2-EPs in gynecological malignancies. RESULTS: This review provides an overview of the current knowledge of COX-2-PGE2-EPs signaling in endometrial cancer, ovarian cancer and cervical cancer. Many studies demonstrated the upregulated expression of the whole signaling pathway in gynecological malignancies and some focused on the function of COX-2 and cAMP-linked EP2/EP4 and EP3 signaling pathway in gynecological cancer. By contrast, roles of EP1 and the exact pathological mechanisms have not been completely clarified. The studies concerning EP receptors in gynecological cancers highlight the potential advantage of combining COX enzyme inhibitors with EP receptor antagonists as therapeutic agents in gynecological cancers. CONCLUSION:
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Authors | Yao Ye, Xipeng Wang, Udo Jeschke, Viktoria von Schönfeldt |
Journal | Archives of gynecology and obstetrics
(Arch Gynecol Obstet)
Vol. 301
Issue 6
Pg. 1365-1375
(06 2020)
ISSN: 1432-0711 [Electronic] Germany |
PMID | 32363546
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Cyclooxygenase 2
- Dinoprostone
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Topics |
- Cyclooxygenase 2
(pharmacology, therapeutic use)
- Dinoprostone
(pharmacology, therapeutic use)
- Female
- Genital Neoplasms, Female
(drug therapy)
- Humans
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