Abstract |
Aberrant expression of stanniocalcin 2 (STC2) is implicated in cancer development. STC2 acts as a tumor promoter to drive some cancers. However, its contribution to the development of pancreatic cancer remains unclear. This study showed that the expression of STC2 was significantly upregulated in pancreatic cancer tissues. Moreover, its expression was positively correlated with tumor size and lymph node metastasis and negatively correlated with 5-year survival rate of pancreatic cancer patients. Additionally, the expression levels of STC2 were a novel biomarker for predicting overall survival rate after surgery. Furthermore, overexpression of STC2 could promote the proliferation, migration, and invasion of pancreatic cancer cell lines, while knocking down of STC2 led to antiproliferation and antimetastasis activities. Further mechanistic investigations revealed that the expression of STC2 could significantly promote the epithelial-mesenchymal transition (EMT) in pancreatic cancer cells. These data indicated that the overexpression of STC2 in pancreatic cancer contributes to the metastasis through the promotion of EMT, suggesting that STC2 is a potential prognostic biomarker and therapeutic target for pancreatic cancer.
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Authors | Chen Lin, Lina Sun, Shenglei Huang, Xiangqun Weng, Zhixian Wu |
Journal | BioMed research international
(Biomed Res Int)
Vol. 2019
Pg. 8042489
( 2019)
ISSN: 2314-6141 [Electronic] United States |
PMID | 32258098
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Chen Lin et al. |
Chemical References |
- Biomarkers, Tumor
- Glycoproteins
- Intercellular Signaling Peptides and Proteins
- STC2 protein, human
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Topics |
- Aged
- Biomarkers, Tumor
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- Epithelial-Mesenchymal Transition
(physiology)
- Female
- Gene Expression Regulation, Neoplastic
- Glycoproteins
(genetics, metabolism)
- HEK293 Cells
- Humans
- Intercellular Signaling Peptides and Proteins
(genetics, metabolism)
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplastic Processes
- Pancreatic Neoplasms
(diagnosis, pathology)
- Prognosis
- Survival Rate
- Up-Regulation
- Wound Healing
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