Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission.

Abstract

BACKGROUND:

Many studies have revealed that mucosal healing improves the long-term prognosis of ulcerative colitis. Frequent colonoscopy is difficult because of its invasiveness and cost. Therefore, in diagnosing and treating ulcerative colitis, noninvasive, low-cost methods for predicting mucosal healing using useful biomarkers are required in the clinical setting. This study aimed to evaluate whether serum amyloid A is a better serum biomarker than C-reactive protein in predicting mucosal healing in ulcerative colitis patients in clinical remission.

METHODS:

Ulcerative colitis patients whose C-reactive protein and serum amyloid A were measured within 1 month before and after colonoscopy were included in this retrospective study, and the relationship between the C-reactive protein and serum amyloid A values and the mucosal condition was analyzed. Mucosal condition was assessed using the Mayo Endoscopic Score, with score 0 or 1 indicating mucosal healing.

RESULTS:

A total of 199 colonoscopic examinations were conducted in 108 ulcerative colitis patients who underwent C-reactive protein and serum amyloid A blood tests. In clinical remission patients, serum amyloid A showed a strong correlation with mucosal inflammation compared to C-reactive protein and had excellent sensitivity and specificity rates with significant statistical significance.

CONCLUSIONS:

Serum amyloid A is a more useful marker compared to C-reactive protein in predicting mucosal inflammation in ulcerative colitis patients in clinical remission.

• Authors: Masaki Wakai, Ryohei Hayashi, Shinji Tanaka, Toshikatsu Naito, Junko Kumada, Motonobu Nomura, Hidehiko Takigawa, Shiro Oka, Yoshitaka Ueno, Masanori Ito, Kazuaki Chayama
• Journal: BMC gastroenterology (BMC Gastroenterol) Vol. 20 Issue 1 Pg. 85 (Apr 03 2020) ISSN: 1471-230X [Electronic] England
• PMID: 32245401 (Publication Type: Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Anti-Inflammatory Agents, Non-Steroidal
• Biological Products
• Biomarkers
• Immunologic Factors
• Serum Amyloid A Protein
• Mesalamine
• C-Reactive Protein

Topics

• Adolescent
• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Aged
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Biological Products (therapeutic use)
• Biomarkers (metabolism)
• C-Reactive Protein (metabolism)
• Child
• Colitis, Ulcerative (drug therapy, metabolism, pathology)
• Colonoscopy
• Female
• Humans
• Immunologic Factors (therapeutic use)
• Intestinal Mucosa (pathology)
• Male
• Mesalamine (therapeutic use)
• Middle Aged
• Remission Induction
• Serum Amyloid A Protein (metabolism)
• Severity of Illness Index
• Young Adult