Tropical pyomyositis: an update.

Abstract

Tropical pyomyositis (TP) is a life-threatening bacterial infection of the skeletal muscle that occurs particularly among children, young adults and those with immunocompromised conditions. The appropriate diagnosis and treatment are often delayed due to its non-specific signs, leading to fatal consequences. Staphylococcus aureus, especially methicillin-susceptible S. aureus, is responsible for most TP cases. However, other bacteria (i.e. streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Candida spp., Mycobacterium spp.) have been reported. This narrative review provides an update on the epidemiology and clinical course of TP. A special focus is laid on the role of toxins (i.e. Panton-Valentine Leucocidin and α-toxin) in the pathogenesis of TP and their implication for the clinical management of infection.

• Authors: Adebayo Shittu, Stefanie Deinhardt-Emmer, Jonathan Vas Nunes, Silke Niemann, Martin P Grobusch, Frieder Schaumburg
• Journal: Tropical medicine & international health : TM & IH (Trop Med Int Health) Vol. 25 Issue 6 Pg. 660-665 (06 2020) ISSN: 1365-3156 [Electronic] England
• PMID: 32219926 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Systematic Review)
• Copyright: © 2020 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd.

Chemical References

• Anti-Bacterial Agents
• Exotoxins

Topics

• Anti-Bacterial Agents (therapeutic use)
• Developing Countries
• Exotoxins (physiology)
• Humans
• Immunocompromised Host
• Pyomyositis (drug therapy, epidemiology, microbiology, physiopathology)
• Staphylococcus aureus (physiology)