Abstract | OBJECTIVE:
Glioma is a primary intracranial tumor with an unfavorable prognosis. Evolving evidence indicates that circular RNA Tau tubulin kinase 2 (circ-TTBK2) is a cancer-associated gene. Therefore, this study was to explore the potential role of circ-TTBK2. MATERIALS AND METHODS: RESULTS: Levels of circ-TTBK2 and ITGB8 were upregulated, whereas miR-761 level was low-expressed in glioma tissues and cells. Circ-TTBK2 was a sponge of miR-761 to modulate ITGB8. Additionally, circ-TTBK2 knockdown or miR-761 increase could retard cell proliferation, invasion, and promote ferroptosis in glioma cells. Interestingly, miR-761 inhibitor could abolish the repressive impact of circ-TTBK2 silencing on cell growth in vitro. Also, the influence of miR-761 mimic on cell phenotypes was regained after ITGB8 upregulation. Meanwhile, circ-TTBK2 deficiency caused the decrease of tumor growth. CONCLUSIONS: Circ-TTBK2 regulated cell proliferation, invasion and ferroptosis via targeting ITGB8 by sponging miR-761 in glioma, providing a promising biomarker for the clinical therapy of human glioma.
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Authors | H-Y Zhang, B-W Zhang, Z-B Zhang, Q-J Deng |
Journal | European review for medical and pharmacological sciences
(Eur Rev Med Pharmacol Sci)
Vol. 24
Issue 5
Pg. 2585-2600
(03 2020)
ISSN: 2284-0729 [Electronic] Italy |
PMID | 32196629
(Publication Type: Journal Article)
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Chemical References |
- ITGB8 protein, human
- Integrin beta Chains
- MicroRNAs
- microRNA761 microRNA, human
- tau-tubulin kinase
- Protein Serine-Threonine Kinases
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Topics |
- Cell Proliferation
- Cells, Cultured
- Ferroptosis
- Glioma
(metabolism, pathology)
- Humans
- Integrin beta Chains
(genetics, metabolism)
- MicroRNAs
(genetics, metabolism)
- Protein Serine-Threonine Kinases
(genetics, metabolism)
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