Somatostatin Analogs in Clinical Practice: a Review.

Abstract

Somatostatin analogs are an invaluable therapeutic option in the diagnosis and treatment of somatotropinomas, thyrotropinomas, and functioning and non-functioning gastroenteropancreatic neuroendocrine tumors. They should also be considered an effective and safe therapeutic alternative to corticotropinomas, gonadotropinomas, and prolactinomas resistant to dopamine agonists. Somatostatin analogs have also shown to be useful in the treatment of other endocrine diseases (congenital hyperinsulinism, Graves' orbitopathy, diabetic retinopathy, diabetic macular edema), non-endocrine tumors (breast, colon, prostate, lung, and hepatocellular), and digestive diseases (chronic refractory diarrhea, hepatorenal polycystosis, gastrointestinal hemorrhage, dumping syndrome, and intestinal fistula).

• Authors: Mariana Gomes-Porras, Jersy Cárdenas-Salas, Cristina Álvarez-Escolá
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 21 Issue 5 (Feb 29 2020) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 32121432 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents, Hormonal
• Somatostatin

Topics

• Antineoplastic Agents, Hormonal (therapeutic use)
• Diabetic Retinopathy (drug therapy, pathology)
• Graves Ophthalmopathy (drug therapy, pathology)
• Growth Hormone-Secreting Pituitary Adenoma (drug therapy, genetics, pathology)
• Humans
• Intestinal Neoplasms (drug therapy, genetics, pathology)
• Macular Edema (drug therapy, pathology)
• Neuroendocrine Tumors (drug therapy, genetics, pathology)
• Pancreatic Neoplasms (drug therapy, genetics, pathology)
• Pituitary Neoplasms (drug therapy, pathology)
• Somatostatin (analogs & derivatives, genetics, therapeutic use)
• Stomach Neoplasms (drug therapy, genetics, pathology)