Abstract | OBJECTIVES: The aims of this study were to compare the characteristics of patients with and without diabetes and to use network analyses to compare biomarker profiles and associated pathways in patients with diabetes compared with those without diabetes, which might offer new avenues for potential therapeutic targets. BACKGROUND: Diabetes adversely affects clinical outcomes and complicates treatment in patients with heart failure (HF). A clear understanding of the pathophysiological processes associated with type 2 diabetes in HF is lacking. METHODS: Network and pathway over-representation analyses were performed to identify unique pathological pathways in patients with and without diabetes using 92 biomarkers from different pathophysiological domains measured in plasma samples from 1,572 patients with HF (31% with diabetes) with reduced ejection fraction (left ventricular ejection fraction <40%). The results were validated in an independent cohort of 729 patients (30% with diabetes). RESULTS: CONCLUSIONS: Concomitant diabetes in patients with HF with reduced ejection fraction is associated with distinct pathophysiological pathways related to inflammation, protein phosphorylation, and neutrophil degranulation. These data support the evaluation of anti-inflammatory therapeutic approaches, epidermal growth factor receptor in particular, for patients with HF and diabetes.
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Authors | Jasper Tromp, Adriaan A Voors, Abhinav Sharma, João P Ferreira, Wouter Ouwerkerk, Hans L Hillege, Karla A Gomez, Kenneth Dickstein, Stefan D Anker, Marco Metra, Chim C Lang, Leong L Ng, Pim van der Harst, Dirk J van Veldhuisen, Peter van der Meer, Carolyn S P Lam, Faiez Zannad, Iziah E Sama |
Journal | JACC. Heart failure
(JACC Heart Fail)
Vol. 8
Issue 3
Pg. 234-242
(03 2020)
ISSN: 2213-1787 [Electronic] United States |
PMID | 32035890
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Biomarkers
(metabolism)
- Diabetes Mellitus, Type 2
(complications, physiopathology)
- Female
- Heart Failure
(complications, metabolism, physiopathology)
- Humans
- Male
- Prognosis
- Prospective Studies
- Stroke Volume
(physiology)
- Ventricular Function, Left
(physiology)
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