Acute pancreatitis (AP) is a rare complication of
hemorrhagic fever with renal syndrome (
HFRS), and is difficult to diagnose. In this study, we retrospectively analyzed the clinical characteristics of 7 cases of
HFRS complicated with AP and 105 cases of acute biliary
pancreatitis (ABP).Medical records of 83 hospitalized patients with
HFRS and 105 hospitalized patients with ABP in the affiliated Yijishan Hospital of Wannan Medical College were reviewed. The comparative analysis of patients between the 2 groups was conducted in terms of sex, age, duration of
hospital stay,
fever,
hemorrhage,
proteinuria,
oliguria, laboratory results, radiologic examinations, and prognosis.A total of 83 patients were diagnosed with
HFRS during study period. Only 8.43% (7/83) of the total
HFRS patients were diagnosed with AP. The differences in the gender, age, and duration of
hospital stay between the 2 investigated groups of patients were not statistically significant. The major symptoms for all 7 patients with
HFRS complicated with AP and 105 patients with ABP were
fever and upper
abdominal pain. During the disease course of
HFRS complicated with AP, 6 patients experienced hemorrhaging, and 7 patients underwent an oliguric stage, but none of the ABP patients experienced hemorrhaging and
oliguria. Among the laboratory results of all patients, the differences in
alanine aminotransferase and glycemia were not statistically significant. The other laboratory results (leucocyte count, platelet count,
amylase,
lipase, total
bilirubin, direct
bilirubin,
creatinine, blood
urea nitrogen, prothrombin time, activated partial thromboplastin time, and serum
calcium level) were significantly different during hospitalization. All 7 patients with
HFRS complicated with AP received conservative medical treatment and
hemodialysis. In the patients with ABP, 21 patients were discharged from the hospital after
conservative treatment, 53 patients were treated by endoscopic invasive treatment after stabilization, and 31 patients were treated by surgery after stabilization.AP is not a frequent complication in patients with
HFRS. There are differences in clinical manifestations and laboratory findings between the
HFRS complicated with AP group and the ABP group; these differences may help in the differential diagnosis and treatment of these 2 types of
pancreatitis.